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. 1989 Nov 25;299(6711):1319–1322. doi: 10.1136/bmj.299.6711.1319

Different lengths of treatment with co-trimoxazole for acute uncomplicated urinary tract infections in women.

T A Trienekens 1, E E Stobberingh 1, R A Winkens 1, A W Houben 1
PMCID: PMC1838181  PMID: 2513939

Abstract

STUDY OBJECTIVE--To compare three days' and seven days' treatment with co-trimoxazole in women with acute dysuria, strangury, and urinary frequency or urgency. DESIGN--Randomised double blind placebo controlled trial. SETTING--General practices in the south east of The Netherlands. PATIENTS--327 Non-pregnant female patients aged 12 to 65. INTERVENTION--161 Women were allocated to three days' treatment (co-trimoxazole 960 mg twice a day), and 166 women were allocated to seven days' treatment (co-trimoxazole 960 mg twice a day). MAIN OUTCOME MEASURE--Resolution of symptoms at one, two, and six weeks. RESULTS--The rates for resolution of symptoms were not significantly different between the two groups. Cumulative rates of recurrence after three days' and seven days' treatment were 31/139 (22%) and 23/151 (15%) respectively six weeks after entry (p = 0.16). Adverse effects occurred in a quarter of women given three days' treatment compared with a third of women receiving seven days' treatment (p = 0.29). In only two patients did adverse effects necessitate stopping treatment. CONCLUSIONS--Three days of co-trimoxazole seems to be as effective as a seven days' course for treating acute urinary tract infection in non-pregnant women.

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Selected References

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