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. Author manuscript; available in PMC: 2007 Mar 30.
Published in final edited form as: Toxicon. 2006 Sep 29;49(2):213–230. doi: 10.1016/j.toxicon.2006.09.024

Fig.3.

Fig.3

Hanatoxin modifies gating of the Kv2.1 channel.

(A) Inhibitory effects of hanatoxin (5 μM) on Kv2.1 channel ionic currents elicited by weak (left) and strong depolarizations (right). Holding voltage was −90 mV and tail voltage was −50 mV. The Kv2.1 was expressed in Xenopus oocytes and studied using a two electrode voltage clamp recording technique. (B) Voltage-activation relations obtained in the absence or presence of 5 μM hanatoxin by measuring tail currents after repolarization to −50 mV following various strength depolarizations and normalized to the maximal value in control.