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. 1983 Jan;23(1):59–62. doi: 10.1128/aac.23.1.59

Nafcillin-induced platelet dysfunction and bleeding.

D P Alexander, M E Russo, D E Fohrman, G Rothstein
PMCID: PMC184617  PMID: 6830209

Abstract

This paper describes two cases of nafcillin-induced platelet dysfunction, with positive rechallenge data for one patient. Nafcillin resulted in abnormal bleeding times in both patients and a clinically apparent bleeding episode in one of the cases. Platelet function tests were performed on one patient during the initial therapy and after rechallenge with nafcillin. Platelet aggregation showed abnormal responses to ADP, collagen, and epinephrine. Platelet count and morphology were normal. Nafcillin should be recognized as another antibiotic which causes platelet function abnormalities and clinical bleeding episodes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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