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. 1983 Mar;23(3):390–396. doi: 10.1128/aac.23.3.390

Inhibition of herpes simplex virus DNA synthesis by pokeweed antiviral protein.

G J Teltow, J D Irvin, G M Aron
PMCID: PMC184658  PMID: 6303210

Abstract

Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus yields than was the simultaneous addition of the antiviral protein with virus inoculum. Viral DNA synthesis was inhibited by 90% in cells which had been exposed to the antiviral protein, whereas cellular DNA synthesis was unaffected. No significant inhibition in the synthesis of the majority of viral infected-cell polypeptides was observed early postinfection (7 h), with the exception of infected cell polypeptides 4 and 41, whose syntheses were reduced by 38 and 25%, respectively. At 9 to 21 h postinfection, however, the synthesis of individual infected cell polypeptides was reduced by 48 to greater than 99%.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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