Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1983 Mar;23(3):397–401. doi: 10.1128/aac.23.3.397

Serotype distribution of penicillin-resistant pneumococci and their susceptibilities to seven antimicrobial agents.

J Michel, D Dickman, Z Greenberg, S Bergner-Rabinowitz
PMCID: PMC184659  PMID: 6847171

Abstract

A total of 229 clinical isolates of Streptococcus pneumoniae recovered from 225 patients were serotyped and tested for susceptibility to penicillin G, ampicillin, mezlocillin, cefazolin, erythromycin, clindamycin, chloramphenicol, and sulfamethoxazole-trimethoprim. Of all the isolates, 48 (21.0%) showed intermediate resistance and 17 (7.4%) showed resistance to penicillin G. Penicillin-resistant strains had higher minimal inhibitory concentrations of ampicillin, mezlocillin, and cefazolin than did penicillin-susceptible strains. Resistance to erythromycin and clindamycin was rare (1.3 and 0.9%, respectively). Of the isolates, 8.7% were resistant to sulfamethoxazole-trimethoprim, and all were susceptible to chloramphenicol. Penicillin resistance was associated with 13 serotypes. Serotypes 14, 19F, 19A, and 23F were both highly prevalent and frequently penicillin resistant.

Full text

PDF
397

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hansman D. Antibiotic sensitivity pattern of pneumococci relatively insensitive to penicillin and cephalosporin antibiotics. Med J Aust. 1975 Nov 8;2(19):740–742. doi: 10.5694/j.1326-5377.1975.tb106245.x. [DOI] [PubMed] [Google Scholar]
  2. Hansman D., Devitt L., Miles H., Riley I. Pneumococci relatively insensitive to penicillin in Australia and New Guinea. Med J Aust. 1974 Sep 7;2(10):353–356. doi: 10.5694/j.1326-5377.1974.tb70836.x. [DOI] [PubMed] [Google Scholar]
  3. Hansman D., Glasgow H., Sturt J., Devitt L., Douglas R. Increased resistance to penicillin of pneumococci isolated from man. N Engl J Med. 1971 Jan 28;284(4):175–177. doi: 10.1056/NEJM197101282840403. [DOI] [PubMed] [Google Scholar]
  4. Howes V. J., Mitchell R. G. Meningitis due to relatively penicillin-resistant pneumococcus. Br Med J. 1976 Apr 24;1(6016):996–996. doi: 10.1136/bmj.1.6016.996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Naraqi S., Kirkpatrick G. P., Kabins S. Relapsing pneumococcal meningitis: isolation of an organism with decreased susceptibility to penicillin G. J Pediatr. 1974 Nov;85(5):671–673. doi: 10.1016/s0022-3476(74)80513-5. [DOI] [PubMed] [Google Scholar]
  6. Robbins J. B., Lee C. J., Rastogi S. C., Schiffman G., Henrichsen J. Comparative immunogenicity of group 6 pneumococcal type 6A(6) and type 6B(26) capsular polysaccharides. Infect Immun. 1979 Dec;26(3):1116–1122. doi: 10.1128/iai.26.3.1116-1122.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Schwartz J. S. Pneumococcal vaccine: clinical efficacy and effectiveness. Ann Intern Med. 1982 Feb;96(2):208–220. doi: 10.7326/0003-4819-96-2-208. [DOI] [PubMed] [Google Scholar]
  8. Shockley T. E., Hotchkiss R. D. Stepwise introduction of transformable penicillin resistance in Pneumococcus. Genetics. 1970 Mar-Apr;64(3):397–408. [PMC free article] [PubMed] [Google Scholar]
  9. Ward J. I., Moellering R. C., Jr Susceptibility of pneumococci to 14 beta-lactam agents: comparison of strains resistant, intermediate-resistant, and susceptible to penicillin. Antimicrob Agents Chemother. 1981 Aug;20(2):204–207. doi: 10.1128/aac.20.2.204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ward J. Antibiotic-resistant Streptococcus pneumoniae: clinical and epidemiologic aspects. Rev Infect Dis. 1981 Mar-Apr;3(2):254–266. doi: 10.1093/clinids/3.2.254. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES