Abstract
The in vitro activity of Sch 29,482, a new oral beta-lactam antimicrobial agent, was compared with those of norfloxacin, rosoxacin, ampicillin, erythromycin, and tetracycline against 142 Neisseria gonorrhoeae strains. Sch 29,482 was as active as norfloxacin and rosoxacin. Its activity was greater than the other three antimicrobial agents. It inhibited 90% of the isolates, regardless of beta-lactamase activity, at a concentration of less than or equal to 0.06 micrograms/ml.
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Selected References
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- Berg S. W., Kilpatrick M. E., Harrison W. O., McCutchan J. A. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1979 Sep 6;301(10):509–511. doi: 10.1056/NEJM197909063011001. [DOI] [PubMed] [Google Scholar]
- Fowler W., Rahim G., Brown J. D. Clinical experience in the use of cefuroxime in gonorrhoea. Br J Vener Dis. 1978 Dec;54(6):400–402. doi: 10.1136/sti.54.6.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gural R., Lin C., Chung M., Oden E., Digiore C. Oral absorption and tolerance in man, of a new penem antibiotic, Sch 29428. J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):239–243. doi: 10.1093/jac/9.suppl_c.239. [DOI] [PubMed] [Google Scholar]
- Handsfield H. H., Judson F. N., Holmes K. K. Treatment of uncomplicated gonorrhea with rosoxacin. Antimicrob Agents Chemother. 1981 Nov;20(5):625–629. doi: 10.1128/aac.20.5.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Handsfield H. H., Murphy V. L., Holmes K. K. Dose-ranging study of ceftriaxone for uncomplicated gonorrhea in men. Antimicrob Agents Chemother. 1981 Dec;20(6):839–840. doi: 10.1128/aac.20.6.839. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Phillips I., King A., Shannon K., Warren C. Sch 29482: in-vitro antibacterial activity and susceptibility to beta-lactamases. J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):25–30. doi: 10.1093/jac/9.suppl_c.25. [DOI] [PubMed] [Google Scholar]