Abstract
The activities of the 2,4-diamino-5-benzylpyrimidines brodimoprim and metioprim against anaerobic bacteria were tested alone and in combination with sulfonamides. Alone they were two to four times more active than trimethoprim, but in combination with sulfonamides, their activity was slightly lower than that of trimethoprim plus sulfamethoxazole.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ferone R., Bushby S. R., Burchall J. J., Moore W. D., Smith D. Identification of Harper-Cawston factor as thymidine phosphorylase and removal from media of substances interfering with susceptibility testing to sulfonamides and diaminopyrimidines. Antimicrob Agents Chemother. 1975 Jan;7(1):91–98. doi: 10.1128/aac.7.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kerry D. W., Hamilton-Miller J. M., Brumfitt W. Trimethoprim and rifampicin: in vitro activities separately and in combination. J Antimicrob Chemother. 1975 Dec;1(4):417–427. doi: 10.1093/jac/1.4.417. [DOI] [PubMed] [Google Scholar]
- Näff H. Uber die Veränderungen der normalen Darmflora des Menschen durch Bactrim. Pathol Microbiol (Basel) 1971;37(1):1–22. [PubMed] [Google Scholar]
- Phillips I., Warren C. Activity of sulfamethoxazole and trimethoprim against Bacteroides fragilis. Antimicrob Agents Chemother. 1976 May;9(5):736–740. doi: 10.1128/aac.9.5.736. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Riley T. V. Agar dilution susceptibility of Bacteroides spp. to sulfamethoxazole and trimethoprim: correlation with a disk diffusion technique. Antimicrob Agents Chemother. 1981 Dec;20(6):731–735. doi: 10.1128/aac.20.6.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rosenblatt J. E., Stewart P. R. Lack of activity of sulfamethoxazole and trimethoprim against anaerobic bacteria. Antimicrob Agents Chemother. 1974 Jul;6(1):93–97. doi: 10.1128/aac.6.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Then R. L., Böhni E., Angehrn P., Plozza-Nottebrock H., Stoeckel K. New analogs of trimethoprim. Rev Infect Dis. 1982 Mar-Apr;4(2):372–377. doi: 10.1093/clinids/4.2.372. [DOI] [PubMed] [Google Scholar]
- Wüst J., Wilkins T. D. Susceptibility of anaerobic bacteria to sulfamethoxazole/trimethoprim and routine susceptibility testing. Antimicrob Agents Chemother. 1978 Sep;14(3):384–390. doi: 10.1128/aac.14.3.384. [DOI] [PMC free article] [PubMed] [Google Scholar]