Abstract
The inability of antimicrobial agents to penetrate scarred renal tissue may explain some therapeutic failures. We examined the effect of scarring on antimicrobial therapy by using a unique animal model in which both kidneys were infected to the same degree but only one kidney was scarred. Scar formation could not explain the failure of ampicillin or nitrofurantoin to eradicate renal infection, but co-trimoxazole was less effective in the presence of tissue damage and scar formation than in their absence.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CARROLL G., BRENNAN R. V. Furadantin. J Urol. 1954 May;71(5):650–654. doi: 10.1016/S0022-5347(17)67839-X. [DOI] [PubMed] [Google Scholar]
- Miller T. E., North D., Burnham S. Acquiescent renal infection. Kidney Int. 1975 Jun;7(6):413–421. doi: 10.1038/ki.1975.59. [DOI] [PubMed] [Google Scholar]
- Miller T., Phillips S. Pyelonephritis: the relationship between infection, renal scarring, and antimicrobial therapy. Kidney Int. 1981 May;19(5):654–662. doi: 10.1038/ki.1981.65. [DOI] [PubMed] [Google Scholar]
- Whelton A., Sapir D. G., Carter G. G., Garth M. A., Walker W. G. Intrarenal distribution of ampicillin in the normal and diseased human kidney. J Infect Dis. 1972 May;125(5):466–470. doi: 10.1093/infdis/125.5.466. [DOI] [PubMed] [Google Scholar]