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. 1983 Apr;23(4):531–535. doi: 10.1128/aac.23.4.531

Relationship between structure and antiplaque and antimicrobial activities for a series of bispyridines.

A M Slee, J R O'Connor, D M Bailey
PMCID: PMC184694  PMID: 6859832

Abstract

A series of bispyridines were examined for their bactericidal activities against in vitro, preformed, pure-culture plaques of selected oral plaque-forming bacteria. The antimicrobial activities of these agents were examined in relation to their molecular configurations. These studies demonstrated that the length of the interpyridine polymethylene group bridge and the length of the alkyl side chain were important determinants of antiplaque and antimicrobial efficacy. The most potent compounds of the bispyridine series were studied to determine the minimal conditions (concentration, duration, and frequency) of treatment required for likely clinical efficacy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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