Abstract
Six healthy volunteers were given single intramuscular injections of an ascending dose schedule of human interferon alpha 2 (Hu IFN alpha 2) from Escherichia coli. At a dose of 3 X 10(6) U, all of the volunteers had febrile reactions with influenza-like symptoms as previously described for purified natural leukocyte interferon. Significant rises in serum 11-hydroxycorticosteroids and falls in plasma zinc levels were observed at this highest dose. Although there was a reduction in the febrile reaction complex, the simultaneous administration of indomethacin with a "toxic" dose of interferon did not alter the changes in white cells, corticosteroids, or trace metals. Nonspecific effects must be considered in the therapeutic activity of interferon.
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Selected References
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- Blalock J. E., Smith E. M. Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5972–5974. doi: 10.1073/pnas.77.10.5972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DE MAEYER E., DE MAEYER J. Two-sided effect of steroids on interferon in tissue culture. Nature. 1963 Feb 16;197:724–725. doi: 10.1038/197724a0. [DOI] [PubMed] [Google Scholar]
- Fumarola D. Toxicity of interferon. Br Med J (Clin Res Ed) 1981 Jul 18;283(6285):235–235. doi: 10.1136/bmj.283.6285.235-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gutterman J. U., Fine S., Quesada J., Horning S. J., Levine J. F., Alexanian R., Bernhardt L., Kramer M., Spiegel H., Colburn W. Recombinant leukocyte A interferon: pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients. Ann Intern Med. 1982 May;96(5):549–556. doi: 10.7326/0003-4819-96-5-549. [DOI] [PubMed] [Google Scholar]
- KILBOURNE E. D., SMART K. M., POKORNY B. A. Inhibition by cortisone of the synthesis and action of interferon. Nature. 1961 May 13;190:650–651. doi: 10.1038/190650a0. [DOI] [PubMed] [Google Scholar]
- Scott G. M., Secher D. S., Flowers D., Bate J., Cantell K., Tyrrell D. A. Toxicity of interferon. Br Med J (Clin Res Ed) 1981 Apr 25;282(6273):1345–1348. doi: 10.1136/bmj.282.6273.1345. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Secher D. S. Immunoradiometric assay of human leukocyte interferon using monoclonal antibody. Nature. 1981 Apr 9;290(5806):501–503. doi: 10.1038/290501a0. [DOI] [PubMed] [Google Scholar]
- Taylor A., Bryant T. N. Comparison of procedures for determination of copper and zinc in serum by atomic absorption spectroscopy. Clin Chim Acta. 1981 Feb 19;110(1):83–90. doi: 10.1016/0009-8981(81)90304-1. [DOI] [PubMed] [Google Scholar]