Abstract
During a therapeutic trial of bicozamycin (BI) for traveler's diarrhea, aerobically grown, gram-negative bacteria, predominantly Escherichia coli, were decreased by 2 to 3 logs per g of stool; the number of BI-resistant gram-negative bacteria did not increase. Resistant species were most often Citrobacter freundii, Klebsiella pneumoniae, and Morganella morganii, and few BI-resistant E. coli strains were isolated. Cross-resistance between BI and other antimicrobial agents was not found. Resistance to BI could not be transferred or mobilized to an E. coli K-12 recipient.
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- Kamiya T., Maeno S., Hashimoto M., Mine Y. Bicyclomycin, a new antibiotic. II. Structural elucidation and acyl derivatives. J Antibiot (Tokyo) 1972 Oct;25(10):576–581. [PubMed] [Google Scholar]
- Miyoshi T., Miyairi N., Aoki H., Kosaka M., Sakai H. Bicyclomycin, a new antibiotic. I. Taxonomy, isolation and characterization. J Antibiot (Tokyo) 1972 Oct;25(10):569–575. doi: 10.7164/antibiotics.25.569. [DOI] [PubMed] [Google Scholar]
- Murray B. E., Moellering R. C., Jr Aminoglycoside-modifying enzymes among clinical isolates of Acinetobacter calcoaceticus subsp. anitratus (Herellea vaginicola): explanation for high-level aminoglycoside resistance. Antimicrob Agents Chemother. 1979 Feb;15(2):190–199. doi: 10.1128/aac.15.2.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murray B. E., Rensimer E. R., DuPont H. L. Emergence of high-level trimethoprim resistance in fecal Escherichia coli during oral administration of trimethoprim or trimethoprim--sulfamethoxazole. N Engl J Med. 1982 Jan 21;306(3):130–135. doi: 10.1056/NEJM198201213060302. [DOI] [PubMed] [Google Scholar]
- Nishida M., Mine Y., Matsubara T., Goto S., Kuwahara S. Bicyclomycin, a new antibiotic. 3. In vitro and in vivo antimicrobial activity. J Antibiot (Tokyo) 1972 Oct;25(10):582–593. [PubMed] [Google Scholar]
- Nishida M., Mine Y., Matsubara T., Goto S., Kuwahara S. Bicyclomycin, a new antibiotic. IV. Absorption, excretion and tissue distribution. J Antibiot (Tokyo) 1972 Oct;25(10):594–601. [PubMed] [Google Scholar]
- Nishida M., Mine Y., Nonoyama S., Kamimura T., Fukada S. Therapeutic efficacy of bicyclomycin for shigellosis experimentally induced in rhesus monkeys. J Antibiot (Tokyo) 1974 Dec;27(12):976–983. doi: 10.7164/antibiotics.27.976. [DOI] [PubMed] [Google Scholar]
- Someya A., Tanaka K., Tanaka N. Morphological changes of Escherichia coli induced by bicyclomycin. Antimicrob Agents Chemother. 1979 Jul;16(1):87–91. doi: 10.1128/aac.16.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]