Abstract
Cefonicid was administered intramuscularly 1 h before open-heart surgery to seven patients in doses of 1 g each and to six patients in doses of 2 g each. Cefonicid concentrations were measured in the right atrial biopsy and in serum at onset of surgery, at time of atrial biopsy, 15 min after starting cardiopulmonary bypass, and at completion of cardiopulmonary bypass. Concentrations in the atrial biopsy and in serum at all periods exceeded the minimal inhibitory concentrations for organisms most frequently responsible for postoperative infections.
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- Boyd R. J., Burke J. F., Colton T. A double-blind clinical trial of prophylactic antibiotics in hip fractures. J Bone Joint Surg Am. 1973 Sep;55(6):1251–1258. [PubMed] [Google Scholar]
- Goldmann D. A., Hopkins C. C., Karchmer A. W., Abel R. M., McEnany M. T., Akins C., Buckley M. J., Moellering R. C., Jr Cephalothin prophylaxis in cardiac valve surgery. A prospective, double-blind comparison of two-day and six-day regimens. J Thorac Cardiovasc Surg. 1977 Mar;73(3):470–479. [PubMed] [Google Scholar]
- Kaiser A. B., Clayson K. R., Mulherin J. L., Jr, Roach A. C., Allen T. R., Edwards W. H., Dale W. A. Antibiotic prophylaxis in vascular surgery. Ann Surg. 1978 Sep;188(3):283–289. doi: 10.1097/00000658-197809000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pitkin D. H., Sachs C., Zajac I., Actor P. Distribution of sodium cefazolin in serum, muscle, bone marrow, and bone of normal rabbits. Antimicrob Agents Chemother. 1977 Apr;11(4):760–762. doi: 10.1128/aac.11.4.760. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pitkin D., Dubb J., Actor P., Alexander F., Ehrlich S., Familiar R., Stote R. Kinetics and renal handling of cefonicid. Clin Pharmacol Ther. 1981 Nov;30(5):587–593. doi: 10.1038/clpt.1981.208. [DOI] [PubMed] [Google Scholar]
- Polk H. C., Jr, Lopez-Mayor J. F. Postoperative wound infection: a prospective study of determinant factors and prevention. Surgery. 1969 Jul;66(1):97–103. [PubMed] [Google Scholar]
- Wallace R. J., Jr, Niefield S. L., Waters S., Waters B., Awe R. J., Wiss K., Martin R. R., Greenberg S. B. Comparative trial of cefonicid and cefamandole in the therapy of community-acquired pneumonia. Antimicrob Agents Chemother. 1982 Feb;21(2):231–235. doi: 10.1128/aac.21.2.231. [DOI] [PMC free article] [PubMed] [Google Scholar]