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. 1962 Oct 20;87(16):852–858.

A 13-15/21 Translocation Chromosome in Carrier Father and Mongol Son

Frederick R Sergovich, Hubert C Soltan, David H Carr
PMCID: PMC1849705  PMID: 13988069

Abstract

Cytogenetic and dermatoglyphic features were studied in a family in which the mongoloid propositus inherited a 13-15/21 translocation chromosome from his father. Seven other healthy male carriers scattered throughout the pedigree produced nine chromosomally normal children and five carrier children in addition to the mongoloid propositus. These results show that carrier males do not necessarily produce an unusually large proportion of carrier children as previous reports would indicate. Dermatoglyphic studies showed that translocation carriers in this family have neither significantly more centralized nor less centralized palmar axial triradii than non-carrier relatives. No direct evidence was therefore found for the hypothesis that an allele is present on chromosome 21 which influences the height of the triradius.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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