Abstract
The activity of combinations of vancomycin (2 or 10 micrograms/ml), gentamicin (0.3 micrograms/ml), and rifampin (0.03 micrograms/ml) against methicillin-resistant, coagulase-negative staphylococcal isolates was determined by the time-kill method. Combinations of rifampin with gentamicin or with vancomycin 2 micrograms/ml demonstrated enhanced killing against 13 of 17 and 13 of 25 strains, respectively. However, rifampin-resistant strains were selected with the latter combination in the remaining 12 of 25 studies.
Full text
PDF![932](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1936/185010/46b1820784e3/aac00207-0142.png)
![933](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1936/185010/3d7478e296d2/aac00207-0143.png)
![934](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1936/185010/601edc4513e4/aac00207-0144.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Archer G. L., Tenenbaum M. J., Haywood H. B., 3rd Rifampin therapy of Staphylococcus epidermidis. Use in infections from indwelling artificial devices. JAMA. 1978 Aug 25;240(8):751–753. [PubMed] [Google Scholar]
- Glew R. H., Millering R. S., Jr, Wennersten C. Comparative synergistic activity of nafcillin, oxacillin, and methicillin in combination with gentamicin against. Antimicrob Agents Chemother. 1975 Jun;7(6):828–832. doi: 10.1128/aac.7.6.828. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lowy F. D., Walsh J. A., Mayers M. M., Klein R. S., Steigbigel N. H. Antibiotic activity in vitro against methicillin-resistant Staphylococcus epidermidis and therapy of an experimental infection. Antimicrob Agents Chemother. 1979 Sep;16(3):314–321. doi: 10.1128/aac.16.3.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lowy F. D., Wexler M. A., Steigbigel N. H. Therapy of methicillin-resistant Staphylococcus epidermidis experimental endocarditis. J Lab Clin Med. 1982 Jul;100(1):94–104. [PubMed] [Google Scholar]
- Miller M. H., Wexler M. A., Steigbigel N. H. Single and combination antibiotic therapy of Staphylococcus aureus experimental endocarditis: emergence of gentamicin-resistant mutants. Antimicrob Agents Chemother. 1978 Sep;14(3):336–343. doi: 10.1128/aac.14.3.336. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sabath L. D., Casey J. I., Ruch P. A., Stumpf L. L., Finland M. Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma. J Lab Clin Med. 1971 Sep;78(3):457–463. [PubMed] [Google Scholar]
- Sabath L. D., Garner C., Wilcox C., Finland M. Susceptibility of Staphylococcus aureus and Staphylococcus epidermidis to 65 antibiotics. Antimicrob Agents Chemother. 1976 Jun;9(6):962–969. doi: 10.1128/aac.9.6.962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Watanakunakorn C., Guerriero J. C. Interaction between vancomycin and rifampin against Staphylococcus aureus. Antimicrob Agents Chemother. 1981 Jun;19(6):1089–1091. doi: 10.1128/aac.19.6.1089. [DOI] [PMC free article] [PubMed] [Google Scholar]