Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1983 Jun;23(6):932–934. doi: 10.1128/aac.23.6.932

Synergy of combinations of vancomycin, gentamicin, and rifampin against methicillin-resistant, coagulase-negative staphylococci.

F D Lowy, D S Chang, P R Lash
PMCID: PMC185010  PMID: 6555016

Abstract

The activity of combinations of vancomycin (2 or 10 micrograms/ml), gentamicin (0.3 micrograms/ml), and rifampin (0.03 micrograms/ml) against methicillin-resistant, coagulase-negative staphylococcal isolates was determined by the time-kill method. Combinations of rifampin with gentamicin or with vancomycin 2 micrograms/ml demonstrated enhanced killing against 13 of 17 and 13 of 25 strains, respectively. However, rifampin-resistant strains were selected with the latter combination in the remaining 12 of 25 studies.

Full text

PDF
932

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Archer G. L., Tenenbaum M. J., Haywood H. B., 3rd Rifampin therapy of Staphylococcus epidermidis. Use in infections from indwelling artificial devices. JAMA. 1978 Aug 25;240(8):751–753. [PubMed] [Google Scholar]
  2. Glew R. H., Millering R. S., Jr, Wennersten C. Comparative synergistic activity of nafcillin, oxacillin, and methicillin in combination with gentamicin against. Antimicrob Agents Chemother. 1975 Jun;7(6):828–832. doi: 10.1128/aac.7.6.828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Lowy F. D., Walsh J. A., Mayers M. M., Klein R. S., Steigbigel N. H. Antibiotic activity in vitro against methicillin-resistant Staphylococcus epidermidis and therapy of an experimental infection. Antimicrob Agents Chemother. 1979 Sep;16(3):314–321. doi: 10.1128/aac.16.3.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lowy F. D., Wexler M. A., Steigbigel N. H. Therapy of methicillin-resistant Staphylococcus epidermidis experimental endocarditis. J Lab Clin Med. 1982 Jul;100(1):94–104. [PubMed] [Google Scholar]
  5. Miller M. H., Wexler M. A., Steigbigel N. H. Single and combination antibiotic therapy of Staphylococcus aureus experimental endocarditis: emergence of gentamicin-resistant mutants. Antimicrob Agents Chemother. 1978 Sep;14(3):336–343. doi: 10.1128/aac.14.3.336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Sabath L. D., Casey J. I., Ruch P. A., Stumpf L. L., Finland M. Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma. J Lab Clin Med. 1971 Sep;78(3):457–463. [PubMed] [Google Scholar]
  7. Sabath L. D., Garner C., Wilcox C., Finland M. Susceptibility of Staphylococcus aureus and Staphylococcus epidermidis to 65 antibiotics. Antimicrob Agents Chemother. 1976 Jun;9(6):962–969. doi: 10.1128/aac.9.6.962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Watanakunakorn C., Guerriero J. C. Interaction between vancomycin and rifampin against Staphylococcus aureus. Antimicrob Agents Chemother. 1981 Jun;19(6):1089–1091. doi: 10.1128/aac.19.6.1089. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES