(A) Apical dendrites expressing GluR2(R607Q) or GluR2(R607Q;S880E). Scale: 10μm.
(B) Over-expression of GluR2(R607Q;S880E) results in a decrease in spine density (GluR2(R607Q) (spines/μm): 0.78±0.03, 43 dendrites, 6 cells, GluR2(R607Q;S880E): 0.66±0.03, n=63 dendrites, 6 cells, p=0.01). p value calculated with t-test
(C) Over-expression of GluR2(R607Q;S880E) depresses AMPA and NMDA EPSCs (normalized to control(pA): AMPA: control: 1.0±0.11(47.1±5.2), GluR2(R607Q;S880E): 0.80± 0.10(37.6±4.8), n=14, p=0.01; NMDA: control: 1.0±0.14(28.7±4.0), GluR2(R607Q:S880E): 0.61 ± 0.07(17.4±2.1), n=13, p<0.01). p values calculated with Wilcoxon test. Scale: 20pA, 20ms. **=p<0.01. *=p<0.05.