Abstract
A study of the metabolic fate of [14C]SM-1652 after intravenous or intramuscular injection into rats showed that: (i) the elimination of the labeled compound from the blood was the same after intravenous and intramuscular injections; (ii) the radiolabeled drug was distributed rapidly and widely after intravenous administration with the highest concentration in the kidney and the lowest in the brain; (iii) placental transmission was slight, as it was passed into the milk, where the concentration was about 14% that of plasma; (iv) 33 and 67% of the administered radioactivity was excreted in urine and feces, respectively; (v) radioactivity in both urine and bile was ascribable to unaltered SM-1652; and (vi) upon repeated intramuscular injections twice daily, levels of labeled SM-1652 in tissue increased gradually, reaching a plateau at the 11th injection.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Kozatani J., Okui M., Noda K., Ogino T., Noguchi H. Cefazolin, a new semisynthetic cephalosporin antibiotic. V. Distribution of cefazolin- 14 C in mice and rats after parenteral administration. Chem Pharm Bull (Tokyo) 1972 Jun;20(6):1105–1113. doi: 10.1248/cpb.20.1105. [DOI] [PubMed] [Google Scholar]
- Matsui H., Yano K., Okuda T. Pharmacokinetics of the cephalosporin SM-1652 in mice, rats, rabbits, dogs, and rhesus monkeys. Antimicrob Agents Chemother. 1982 Aug;22(2):213–217. doi: 10.1128/aac.22.2.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matsuzaki M., Matsumoto H., Ochiai K., Tashiro Y., Hino M. [Absorption, distribution and excretion of 14C-cefatrizine (14C-S-640 P) in rat (author's transl)]. Jpn J Antibiot. 1976 Apr;29(4):391–402. [PubMed] [Google Scholar]
- Nakai Y., Kanai Y., Fugono T., Tanayama S. Metabolic fate of cephacetrile after parenteral administration in rats and rabbits. J Antibiot (Tokyo) 1976 Jan;29(1):81–90. doi: 10.7164/antibiotics.29.81. [DOI] [PubMed] [Google Scholar]
- Saikawa I., Takai A., Nakashima Y., Ikegami T., Hayakawa H., Takagi T., Yamauchi H. [Studies on the absorption distribution and excretion of 14C-labelled sodium 7-[D(-)-alpha-(4-ethyl-2,3-dioxo-1-piperazine-carboxamido)-alpha-(4-hydroxyphenyl l) acetamido]-3-[(1-methyl-1H-tetrazol-5-yl) thiomethyl]-3-cephem-4-carboxylate (14C-cefoperazone) in rats and mice]. Jpn J Antibiot. 1980 Oct;33(10):1084–1096. [PubMed] [Google Scholar]
- Tanayama S., Kondo T., Kanai Y. Metabolic fate of SCE-963, a new broad-spectrum cephalosporin, after parenteral administration in rats and dogs. J Antibiot (Tokyo) 1978 Jul;31(7):703–711. doi: 10.7164/antibiotics.31.703. [DOI] [PubMed] [Google Scholar]
- Tanayama S., Yoshida K., Adachi K., Kondo T. Metabolic fate of SCE-1365, a new broad-spectrum cephalosporin, after parenteral administration to rats and dogs. Antimicrob Agents Chemother. 1980 Oct;18(4):511–518. doi: 10.1128/aac.18.4.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ULLBERG S. Studies on the distribution and fate of S35-labelled benzylpenicillin in the body. Acta Radiol Suppl. 1954;118:1–110. [PubMed] [Google Scholar]