Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1983 Jul;24(1):129–131. doi: 10.1128/aac.24.1.129

Effect of discontinuous acyclovir treatment on in vitro reactivation of herpes simplex virus from latently infected trigeminal ganglia.

R J Klein, A E Friedman-Kien, E DeStefano
PMCID: PMC185116  PMID: 6312871

Abstract

Exposing explant cultures of latently infected mouse trigeminal ganglia alternately to acyclovir-containing and drug-free medium led to a significant decrease in the proportion of ganglia containing reactivatable herpes simplex virus. The loss of virus from the explant cultures was not caused by thermal inactivation during prolonged incubation periods. The efficiency of virus elimination may depend on the frequency and duration of the alternating treatment and on the number of latently infected neurons in the ganglia.

Full text

PDF
129

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blyth W. A., Harbour D. A., Hill T. J. Effect of acyclovir on recurrence of herpes simplex skin lesions in mice. J Gen Virol. 1980 Jun;48(Pt 2):417–419. doi: 10.1099/0022-1317-48-2-417. [DOI] [PubMed] [Google Scholar]
  2. Field H. J., Bell S. E., Elion G. B., Nash A. A., Wildy P. Effect of acycloguanosine treatment of acute and latent herpes simplex infections in mice. Antimicrob Agents Chemother. 1979 Apr;15(4):554–561. doi: 10.1128/aac.15.4.554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Field H. J., De Clercq E. Effects of oral treatment with acyclovir and bromovinyldeoxyuridine on the establishment of maintenance of latent herpes simplex virus infection in mice. J Gen Virol. 1981 Oct;56(Pt 2):259–265. doi: 10.1099/0022-1317-56-2-259. [DOI] [PubMed] [Google Scholar]
  4. Field H. J., Wildy P. Recurrent herpes simplex: the outlook for systemic antiviral agents. Br Med J (Clin Res Ed) 1981 Jun 6;282(6279):1821–1822. doi: 10.1136/bmj.282.6279.1821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Klein R. J., DeStefano E., Friedman-Kien A. E., Brady E. Effect of acyclovir on latent herpes simplex virus infections in trigeminal ganglia of mice. Antimicrob Agents Chemother. 1981 May;19(5):937–939. doi: 10.1128/aac.19.5.937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Klein R. J., Friedman-Kien A. E., DeStefano E. Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine. Antimicrob Agents Chemother. 1979 May;15(5):723–729. doi: 10.1128/aac.15.5.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Klein R. J. Treatment of experimental latent herpes simplex virus infections with acyclovir and other antiviral compounds. Am J Med. 1982 Jul 20;73(1A):138–142. doi: 10.1016/0002-9343(82)90079-1. [DOI] [PubMed] [Google Scholar]
  8. Park N. H., Pavan-Langston D., Declercq E. Effect of acyclovir, bromovinyldeoxyuridine, vidarabine, and L-lysine on latent ganglionic herpes simplex virus in vitro. Am J Med. 1982 Jul 20;73(1A):151–154. doi: 10.1016/0002-9343(82)90081-x. [DOI] [PubMed] [Google Scholar]
  9. Pavan-Langston D., Park N. H., Hettinger M. Ganglionic herpes simplex and systemic acyclovir. Arch Ophthalmol. 1981 Aug;99(8):1417–1419. doi: 10.1001/archopht.1981.03930020291019. [DOI] [PubMed] [Google Scholar]
  10. Svennerholm B., Vahlne A., Lycke E. Persistent reactivable latent herpes simplex virus infection in trigeminal ganglia of mice treated with antiviral drugs. Arch Virol. 1981;69(1):43–48. doi: 10.1007/BF01315264. [DOI] [PubMed] [Google Scholar]
  11. Trousdale M. D., Dunkel E. C., Nesburn A. B. Effect of acyclovir on acute and latent herpes simplex virus infections in the rabbit. Invest Ophthalmol Vis Sci. 1980 Nov;19(11):1336–1341. [PubMed] [Google Scholar]
  12. Watson K., Stevens J. G., Cook M. L., Subak-Sharpe J. H. Latency competence of thirteen HSV-1 temperature-sensitive mutants. J Gen Virol. 1980 Jul;49(1):149–159. doi: 10.1099/0022-1317-49-1-149. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES