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. 1983 Jul;24(1):134–136. doi: 10.1128/aac.24.1.134

Treatment of intracranial dengue virus infections in mice with a lipophilic derivative of ribavirin.

W C Koff, R D Pratt, J L Elm Jr, C N Venkateshan, S B Halstead
PMCID: PMC185118  PMID: 6684897

Abstract

Rimantadine, ribavirin, and 6-mercapto-9-(tetrahydro-2-furyl)purine, administered intraperitoneally every 8 h for 7 days starting minutes after virus challenge, had no effect on survival and mean survival time of BALB/c mice inoculated intracranially with dengue virus type 2. In contrast, intraperitoneal treatment with ribavirin 2',3',5'-triacetate, a lipophilic analog of ribavirin, effected significant increases in both mean survival time and survival rate, suggesting that ribavirin 2',3',5'-triacetate may be superior to rabavirin for treatment of viral diseases of the brain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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