Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Diagram of patient CD3ζ mutation. The extracellular (EC), transmembrane (TM), and 3 intracellular ITAMs of wild-type CD3ζ protein are depicted along with the location of the homozygous patient mutation and the recognition site of the anti-CD3ζ Ab used in the present study. Wild-type (WT) and patient (MUT) CD3ζ amino acid sequences in the region affected by the mutation are shown in the expanded view. X indicates stop codon; and fs, frameshift.
