Abstract
The minimal inhibitory concentrations of Rodogyl (composite tablet of metronidazole and spiramycin), metronidazole-spiramycin mixture, spiramycin, metronidazole, and tetracycline were determined for selected putative periodontopathic microorganisms. Rodogyl was active against almost all strains, including Bacteroides species and the anaerobic spirochetes. Synergism of the component drugs in the Rodogyl combination was noted against Propionibacterium species. Spiramycin activity against Actinomyces species was enhanced in the presence of metronidazole.
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Selected References
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- Brown A. A. Anti-infectives. Ont Dent. 1976 Dec;53(12):7–11. [PubMed] [Google Scholar]
- Chan E. C., De Vries J., Harvey R. F., Tam Y. C. Use of fluorescence microscopy for monitoring periodontal disease state. Can J Microbiol. 1981 Jul;27(7):675–678. doi: 10.1139/m81-104. [DOI] [PubMed] [Google Scholar]
- Chan E. C., deVries J., Harvey R. F., Alfieri C. Bacteroides species and gelatinase-producers in periodontal disease. J Can Dent Assoc. 1982 Feb;48(2):112–114. [PubMed] [Google Scholar]
- Darwish S., Hyppa T., Socransky S. S. Studies of the predominant cultivable microbiota of early periodontitis. J Periodontal Res. 1978 Jan;13(1):1–16. doi: 10.1111/j.1600-0765.1978.tb00149.x. [DOI] [PubMed] [Google Scholar]
- Genco R. J. Antibiotics in the treatment of human periodontal diseases. J Periodontol. 1981 Sep;52(9):545–558. doi: 10.1902/jop.1981.52.9.545. [DOI] [PubMed] [Google Scholar]
- Kamme C., Kahlmeter G., Melander A. Evaluation of spiramycin as a therapeutic agent for elimination of nasopharyngeal pathogens. Possible use of spiramycin for middle ear infections and for gonococcal and meningococcal nasopharyngeal carriage. Scand J Infect Dis. 1978;10(2):135–142. doi: 10.3109/inf.1978.10.issue-2.07. [DOI] [PubMed] [Google Scholar]
- Laufer J., Mignon H., Videau D. L'association métronidazole-spiramycine. Concentrations et synergie in situ comparées aux CMI de la flore buccale. Rev Stomatol Chir Maxillofac. 1974 Jul-Aug;74(5):387–392. [PubMed] [Google Scholar]
- Leschine S. B., Canale-Parola E. Rifampin as a selective agent for isolation of oral spirochetes. J Clin Microbiol. 1980 Dec;12(6):792–795. doi: 10.1128/jcm.12.6.792-795.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Listgarten M. A., Helldén L. Relative distribution of bacteria at clinically healthy and periodontally diseased sites in humans. J Clin Periodontol. 1978 May;5(2):115–132. doi: 10.1111/j.1600-051x.1978.tb01913.x. [DOI] [PubMed] [Google Scholar]
- Listgarten M. A., Levin S. Positive correlation between the proportions of subgingival spirochetes and motile bacteria and susceptibility of human subjects to periodontal deterioration. J Clin Periodontol. 1981 Apr;8(2):122–138. doi: 10.1111/j.1600-051x.1981.tb02352.x. [DOI] [PubMed] [Google Scholar]
- Loesche W. J., Syed S. A., Morrison E. C., Laughon B., Grossman N. S. Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole. J Clin Periodontol. 1981 Feb;8(1):29–44. doi: 10.1111/j.1600-051x.1981.tb02022.x. [DOI] [PubMed] [Google Scholar]
- Newman M. G. The role of Bacteroides melaninogenicus and other anaerobes in periodontal infections. Rev Infect Dis. 1979 Mar-Apr;1(2):313–324. doi: 10.1093/clinids/1.2.313. [DOI] [PubMed] [Google Scholar]
- Winer R. A., Cohen M. M., Chauncey H. H. Antibiotic therapy in periodontal disease. J Oral Ther Pharmacol. 1966 May;2(6):403–410. [PubMed] [Google Scholar]