Abstract
The role of corticosterone, a potent in vitro inhibitor of extraneuronal uptake, in the regulation of the extraneuronal accumulation of [3H]-isoprenaline into rat atria was examined. Procedures which increased plasma corticosterone levels resulted in a decrease in the corticosterone-sensitive component of extraneuronal accumulation of [3H]-isoprenaline (64% after reserpine treatment and 25% after chronic cold exposure). Procedures which decreased levels of plasma corticosterone resulted in an increase in the corticosterone-sensitive component of extraneuronal accumulation of [3H]-isoprenaline (approximately 20% after adrenalectomy and 32% after hypophysectomy). This increase was partially prevented by the in vivo administration of dexamethasone (40 micrograms kg-1). There was a strong inverse correlation between the plasma corticosterone concentration and the level of extraneuronal uptake into atria (P less than 0.01). Corticosterone appears to play a major role in the regulation of extraneuronal uptake into tissues of the rat.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bassett J. M., Hinks N. T. Micro-determination of corticosteroids in ovine peripheral plasma: effects of venipuncture, corticotrophin, insulin and glucose. J Endocrinol. 1969 Jul;44(3):387–403. doi: 10.1677/joe.0.0440387. [DOI] [PubMed] [Google Scholar]
- Bryan L. J., O'Donnell S. R., Williams A. M. The effects of thyroxine treatment of rats on neuronal and extraneuronal uptake and metabolism of catecholamines in the heart. Br J Pharmacol. 1986 Feb;87(2):337–344. doi: 10.1111/j.1476-5381.1986.tb10822.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chaffee R. R., Roberts J. C. Temperature acclimation in birds and mammals. Annu Rev Physiol. 1971;33:155–202. doi: 10.1146/annurev.ph.33.030171.001103. [DOI] [PubMed] [Google Scholar]
- Foster P. S., Goldie R. G., Paterson J. W. Effect of steroids on beta-adrenoceptor-mediated relaxation of pig bronchus. Br J Pharmacol. 1983 Feb;78(2):441–445. doi: 10.1111/j.1476-5381.1983.tb09409.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gibson A. The influence of endocrine hormones on the autonomic nervous system. J Auton Pharmacol. 1981 Sep;1(4):331–358. doi: 10.1111/j.1474-8673.1981.tb00463.x. [DOI] [PubMed] [Google Scholar]
- Hodges J. R. The hypothalamo-pituitary-adrenocortical system. J Pharm Pharmacol. 1976 Apr;28(4 Suppl):397–382. [PubMed] [Google Scholar]
- Iversen L. L., De Champlain J., Glowinski J., Axelrod J. Uptake, storage and metabolism of norepinephrine in tissues of the developing rat. J Pharmacol Exp Ther. 1967 Sep;157(3):509–516. [PubMed] [Google Scholar]
- Morton A. J. An investigation of the role of adrenergic innervation in the regulation of the extraneuronal uptake of [3H]-isoprenaline into rat vasa deferentia and atria. Br J Pharmacol. 1987 Jun;91(2):333–346. doi: 10.1111/j.1476-5381.1987.tb10288.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morton A. J. The effect of reserpine treatment on the extraneuronal uptake of [3H]-isoprenaline into rat atria. Br J Pharmacol. 1985 Sep;86(1):287–295. doi: 10.1111/j.1476-5381.1985.tb09460.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parvez S., Raza-Bukhari A., Ismahan G. The influence of hypophysectomy, adrenalectomy, progesterone, oxytocin, and estradiol on the metabolic fate of 3H-epinephrine in central and peripheral regions during late pregnancy. Am J Obstet Gynecol. 1979 May 1;134(1):13–19. doi: 10.1016/0002-9378(79)90788-9. [DOI] [PubMed] [Google Scholar]
- Pohorecky L. A., Wurtman R. J. Adrenocortical control of epinephrine synthesis. Pharmacol Rev. 1971 Mar;23(1):1–35. [PubMed] [Google Scholar]
- Salt P. J. Inhibition of noradrenaline uptake 2 in the isolated rat heart by steroids, clonidine and methoxylated phenylethylamines. Eur J Pharmacol. 1972 Dec;20(3):329–340. doi: 10.1016/0014-2999(72)90194-x. [DOI] [PubMed] [Google Scholar]
- Trendelenburg U. A kinetic analysis of the extraneuronal uptake and metabolism of catecholamines. Rev Physiol Biochem Pharmacol. 1980;87:33–115. doi: 10.1007/BFb0030896. [DOI] [PubMed] [Google Scholar]