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. 1987 Dec;92(4):695–701. doi: 10.1111/j.1476-5381.1987.tb11373.x

Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells.

D Crossman 1, J McEwan 1, J MacDermot 1, I MacIntyre 1, C T Dollery 1
PMCID: PMC1853704  PMID: 3322463

Abstract

1 Endothelial cells of human umbilical vein were isolated and cultured in vitro. 2 In these cells there was a concentration-dependent release of prostacyclin and activation of adenylate cyclase by human calcitonin gene-related peptide (hCGRP). The concentration of hCGRP for half-maximum activation of adenylate cyclase (Kact) by hCGRP was 190 nM. 3 Bradykinin induced a ten fold greater release of prostacyclin than CGRP, but did not activate adenylate cyclase. 4 hCGRP may exert its potent vasodilator properties by stimulating release of vasorelaxant substances, including prostacyclin from endothelial cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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