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. 1988 Apr;93(4):747–750. doi: 10.1111/j.1476-5381.1988.tb11458.x

Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs.

R M Tripathi 1, R Kaushal 1
PMCID: PMC1853872  PMID: 3390649

Abstract

1. Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied. 2. Ventricular premature beats, ventricular fibrillation and cardiac arrest were induced in pentobarbitone-anaesthetized guinea-pigs by a slow intravenous infusion of ouabain. 3. Aspirin and indomethacin were found to accord a significant protection to the guinea-pigs against arrhythmias whereas ketoprofen was found to be ineffective. 4. It is concluded that the protective effect of aspirin and indomethacin may be due to inhibition of synthesis and release of thromboxane A2 from the myocardium.

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Selected References

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  1. Black J. W., Shankley N. P. Pharmacological analysis of the inhibition by pirenzepine and atropine of vagal-stimulated acid secretion in the isolated stomach of the mouse. Br J Pharmacol. 1986 May;88(1):291–297. doi: 10.1111/j.1476-5381.1986.tb09498.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brasch H. Protective effects of Na salicylate against digoxin- and BaCl2-induced arrhythmias in guinea-pigs. Eur J Pharmacol. 1984 Feb 17;98(2):297–301. doi: 10.1016/0014-2999(84)90606-x. [DOI] [PubMed] [Google Scholar]
  3. Burke S. E., Lefer A. M., Nicolaou K. C., Smith G. M., Smith J. B. Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues. Br J Pharmacol. 1983 Feb;78(2):287–292. doi: 10.1111/j.1476-5381.1983.tb09393.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Campbell C. A., Przyklenk K., Kloner R. A. Infarct size reduction: a review of the clinical trials. J Clin Pharmacol. 1986 May-Jun;26(5):317–329. doi: 10.1002/j.1552-4604.1986.tb03532.x. [DOI] [PubMed] [Google Scholar]
  5. Coker S. J., Ledingham I. M., Parratt J. R., Zeitlin I. J. Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs. Br J Pharmacol. 1981 Apr;72(4):593–595. doi: 10.1111/j.1476-5381.1981.tb09138.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Coker S. J., Parratt J. R. The effects of prostaglandins E2, F2 alpha, prostacyclin, flurbiprofen and aspirin on arrhythmias resulting from coronary artery ligation in anaesthetized rats. Br J Pharmacol. 1981 Sep;74(1):155–159. doi: 10.1111/j.1476-5381.1981.tb09968.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Colasanti B. K., Barany E. H. Reduction by indomethacin of the degeneration increase in outflow facility after superior cervical ganglionectomy in the rabbit. Invest Ophthalmol Vis Sci. 1978 Aug;17(8):802–805. [PubMed] [Google Scholar]
  8. Darius H., Smith J. B., Lefer A. M. Beneficial effects of a new potent and specific thromboxane receptor antagonist (SQ-29,548) in vitro and in vivo. J Pharmacol Exp Ther. 1985 Nov;235(2):274–281. [PubMed] [Google Scholar]
  9. Ellis E. F., Oelz O., Roberts L. J., 2nd, Payne N. A., Sweetman B. J., Nies A. S., Oates J. A. Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2. Science. 1976 Sep 17;193(4258):1135–1137. doi: 10.1126/science.959827. [DOI] [PubMed] [Google Scholar]
  10. Elwood P. C., Sweetnam P. M. Aspirin and secondary mortality after myocardial infarction. Lancet. 1979 Dec 22;2(8156-8157):1313–1315. doi: 10.1016/s0140-6736(79)92808-3. [DOI] [PubMed] [Google Scholar]
  11. Fagbemi S. O. The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats. Eur J Pharmacol. 1984 Jan 27;97(3-4):283–287. doi: 10.1016/0014-2999(84)90461-8. [DOI] [PubMed] [Google Scholar]
  12. Fleckenstein A., Byon K. Y. Proceedings: Prevention by Ca-antagonistic compounds (verapamil, D 600) of coronary smooth muscle contractures due to treatment with cardiac glycosides. Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282–282:R20. [PubMed] [Google Scholar]
  13. Fleckenstein A., Fleckenstein-Grün G., Byon Y. K., Haastert H. P., Späh F. Vergleichende Untersuchungen über die Ca++-antagonistischen Grundwirkungen von Niludipin (Bay a 7168) und Nifedipin (Bay a 1040) auf Myokard, Myometrium und glatte Gefässmuskulatur. Arzneimittelforschung. 1979;29(2):230–246. [PubMed] [Google Scholar]
  14. Flores A. G., Sharp G. W. Endogenous prostaglandins and osmotic water flow in the toad bladder. Am J Physiol. 1972 Dec;223(6):1392–1397. doi: 10.1152/ajplegacy.1972.223.6.1392. [DOI] [PubMed] [Google Scholar]
  15. Hammerman H., Kloner R. A., Schoen F. J., Brown E. J., Jr, Hale S., Braunwald E. Indomethacin-induced scar thinning after experimental myocardial infarction. Circulation. 1983 Jun;67(6):1290–1295. doi: 10.1161/01.cir.67.6.1290. [DOI] [PubMed] [Google Scholar]
  16. Jugdutt B. I., Hutchins G. M., Bulkley B. H., Pitt B., Becker L. C. Effect of indomethacin on collateral blood flow and infarct size in the conscious dog. Circulation. 1979 Apr;59(4):734–743. doi: 10.1161/01.cir.59.4.734. [DOI] [PubMed] [Google Scholar]
  17. Korbut R., Moncada S. Prostacyclin (PGI2) and thromboxane A2 interaction in vivo. Regulation by aspirin and relationship with anti-thrombotic therapy. Thromb Res. 1978 Sep;13(3):489–500. doi: 10.1016/0049-3848(78)90134-2. [DOI] [PubMed] [Google Scholar]
  18. Lefer A. M. Eicosanoids as mediators of ischemia and shock. Fed Proc. 1985 Feb;44(2):275–280. [PubMed] [Google Scholar]
  19. Northover B. J. The antagonism between anti-inflammatory drugs and substances that constrict veins. J Pathol Bacteriol. 1967 Jul;94(1):206–212. doi: 10.1002/path.1700940129. [DOI] [PubMed] [Google Scholar]
  20. Piper P. J. Anaphylaxis and the release of active substances in the lungs. Pharmacol Ther B. 1977;3(1):75–98. doi: 10.1016/0306-039x(77)90005-8. [DOI] [PubMed] [Google Scholar]
  21. Smith J. B., Willis A. L. Aspirin selectively inhibits prostaglandin production in human platelets. Nat New Biol. 1971 Jun 23;231(25):235–237. doi: 10.1038/newbio231235a0. [DOI] [PubMed] [Google Scholar]
  22. Tachizawa H., Tsukada W., Saito T., Akimoto T. Prostaglandin synthetase systems in rat and rabbit renal medulla and inhibition by non-steroidal anti-inflammatory drugs. Jpn J Pharmacol. 1977 Jun;27(3):351–359. doi: 10.1254/jjp.27.351. [DOI] [PubMed] [Google Scholar]
  23. Thomas G. P., Tripathi R. M. Effects of alpha-adrenoceptor agonists and antagonists on ouabain-induced arrhythmias and cardiac arrest in guinea-pig. Br J Pharmacol. 1986 Oct;89(2):385–388. doi: 10.1111/j.1476-5381.1986.tb10271.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Vane J. R. The mode of action of aspirin and similar compounds. J Allergy Clin Immunol. 1976 Dec;58(6):691–712. doi: 10.1016/0091-6749(76)90181-0. [DOI] [PubMed] [Google Scholar]
  25. Walinsky P., Smith J. B., Lefer A. M., Lebenthal M., Urban P., Greenspon A., Goldberg S. Thromboxane A2 in acute myocardial infarction. Am Heart J. 1984 Oct;108(4 Pt 1):868–872. doi: 10.1016/0002-8703(84)90447-2. [DOI] [PubMed] [Google Scholar]

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