Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1983 Dec;24(6):902–904. doi: 10.1128/aac.24.6.902

Selective decontamination of the digestive tract by pipemidic acid.

H L Muytjens, G L van Veldhuizen, G W Welling, J van der Ros-van de Repe, H B Boerema, D van der Waaij
PMCID: PMC185404  PMID: 6419675

Abstract

The possible use of pipemidic acid for preventing infections in granulocytopenic patients by selective elimination of the gram-negative rods from the digestive tract was evaluated. Fecal samples were collected before, during, and after therapy from 23 adults who were undergoing treatment of urinary tract infections with pipemidic acid at a dosage of 200 mg orally four times daily for 10 days. The concentration of pipemidic acid in the majority of the stool samples tested was 220 to 600 micrograms/g. However, in 19% of the samples collected on day 5, the concentration was below the detection limit (23 micrograms/ml). Approximately 90% of the fecal samples collected during or shortly after therapy were negative for members of the family Enterobacteriaceae. Resistance of the gastrointestinal tract against colonization by microorganisms from the environment (so-called colonization resistance) remained unimpaired, as measured by the absence of beta-aspartylglycine in the stool.

Full text

PDF
902

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dekker A. W., Rozenberg-Arska M., Sixma J. J., Verhoef J. Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia. Ann Intern Med. 1981 Nov;95(5):555–559. doi: 10.7326/0003-4819-95-5-555. [DOI] [PubMed] [Google Scholar]
  2. Muytjens H. L., van der Ros-van de Repe J., van Veldhuizen G. Comparative activities of ciprofloxacin (Bay o 9867), norfloxacin, pipemidic acid, and nalidixic acid. Antimicrob Agents Chemother. 1983 Aug;24(2):302–304. doi: 10.1128/aac.24.2.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Schimpff S. C., Young V. M., Greene W. H., Vermeulen G. D., Moody M. R., Wiernik P. H. Origin of infection in acute nonlymphocytic leukemia. Significance of hospital acquisition of potential pathogens. Ann Intern Med. 1972 Nov;77(5):707–714. doi: 10.7326/0003-4819-77-5-707. [DOI] [PubMed] [Google Scholar]
  4. Shimizu M., Nakamura S., Takase Y., Kurobe N. Pipemidic acid: absorption, distribution, and excretion. Antimicrob Agents Chemother. 1975 Apr;7(4):441–446. doi: 10.1128/aac.7.4.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Sleijfer D. T., Mulder N. H., de Vries-Hospers H. G., Fidler V., Nieweg H. O., van der Waaij D., van Saene H. K. Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Eur J Cancer. 1980 Jun;16(6):859–869. doi: 10.1016/0014-2964(80)90140-1. [DOI] [PubMed] [Google Scholar]
  6. Welling G. W. Comparison of methods for the determination of beta-aspartylglycine in fecal supernatants of leukemic patients treated with antimicrobial agents. J Chromatogr. 1982 Oct 8;232(1):55–62. doi: 10.1016/s0378-4347(00)86007-7. [DOI] [PubMed] [Google Scholar]
  7. Welling G. W., Groen G., Tuinte J. H., Koopman J. P., Kennis H. M. Biochemical effects on germ-free mice of association with several strains of anaerobic bacteria. J Gen Microbiol. 1980 Mar;117(1):57–63. doi: 10.1099/00221287-117-1-57. [DOI] [PubMed] [Google Scholar]
  8. Wilson J. M., Guiney D. G. Failure of oral trimethoprim-sulfamethoxazole prophylaxis in acute leukemia: isolation of resistant plasmids from strains of Enterobacteriaceae causing bacteremia. N Engl J Med. 1982 Jan 7;306(1):16–20. doi: 10.1056/NEJM198201073060105. [DOI] [PubMed] [Google Scholar]
  9. de Vries-Hospers H. G., Sleijfer D. T., Mulder N. H., van der Waaij D., Neiweg H. O., van Saene H. K. Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients. Antimicrob Agents Chemother. 1981 May;19(5):813–820. doi: 10.1128/aac.19.5.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. van der Waaij D., Aberson J., Thijm H. A., Welling G. W. The screening of four aminoglycosides in the selective decontamination of the digestive tract in mice. Infection. 1982 Jan;10(1):35–40. doi: 10.1007/BF01640836. [DOI] [PubMed] [Google Scholar]
  11. van der Waaij D., Berghuis-de Vries J. M., Lekkerkerk Lekkerkerk-v Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. J Hyg (Lond) 1971 Sep;69(3):405–411. doi: 10.1017/s0022172400021653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. van der Waaij D., Berghuis-de Vries J. M. Selective elimination of Enterobacteriaceae species from the digestive tract in mice and monkeys. J Hyg (Lond) 1974 Apr;72(2):205–211. doi: 10.1017/s002217240002341x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. van der Waaij D. Colonization resistance of the digestive tract: clinical consequences and implications. J Antimicrob Chemother. 1982 Oct;10(4):263–270. doi: 10.1093/jac/10.4.263. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES