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. 1988 Dec;95(4):1191–1196. doi: 10.1111/j.1476-5381.1988.tb11755.x

Dietary omega 3 polyunsaturated fatty acids augment endothelium-dependent relaxation to bradykinin in coronary microvessels of the pig.

H Shimokawa 1, L L Aarhus 1, P M Vanhoutte 1
PMCID: PMC1854250  PMID: 2851360

Abstract

1. The effects of chronic dietary supplementation with omega 3 polyunsaturated fatty acids on endothelium-dependent relaxations were examined in isolated coronary microvessels of the pig. 2. Animals were maintained for four weeks with or without dietary supplementation of purified eicosapentaenoic acid (3.5 g daily) and docosahexaenoic acid (1.5 g daily). Fatty acid profiles of plasma lipids showed that only the fraction of eicosapentaenoic acid increased by the treatment, together with a decrease of that of arachidonic acid. 3. In the treated group, endothelium-dependent relaxations to bradykinin were significantly augmented, while contractions to acetylcholine or relaxations to nitroprusside were unaltered. 4. These results indicate that dietary omega 3 polyunsaturated fatty acids (mainly eicosapentaenoic acid) augment endothelium-dependent relaxations in coronary microvessels of the pig, without changing the ability of vascular smooth muscle to contract or relax.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrews H. E., Bruckdorfer K. R., Dunn R. C., Jacobs M. Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature. 1987 May 21;327(6119):237–239. doi: 10.1038/327237a0. [DOI] [PubMed] [Google Scholar]
  2. Busse R., Trogisch G., Bassenge E. The role of endothelium in the control of vascular tone. Basic Res Cardiol. 1985 Sep-Oct;80(5):475–490. doi: 10.1007/BF01907912. [DOI] [PubMed] [Google Scholar]
  3. ELLEFSON R. D., MASON H. L. EFFECTS OF DEFICIENCY AND EXCESS OF THYROID HORMONE ON THE DISTRIBUTION OF FATTY ACIDS IN LIPIDS OF THE RAT. Endocrinology. 1964 Aug;75:179–186. doi: 10.1210/endo-75-2-179. [DOI] [PubMed] [Google Scholar]
  4. Furchgott R. F., Jothianandan D., Cherry P. D. Endothelium-dependent responses: the last three years. Bibl Cardiol. 1984;(38):1–15. [PubMed] [Google Scholar]
  5. Furchgott R. F. Role of endothelium in responses of vascular smooth muscle. Circ Res. 1983 Nov;53(5):557–573. doi: 10.1161/01.res.53.5.557. [DOI] [PubMed] [Google Scholar]
  6. Gospodarowicz D., Delgado D., Vlodavsky I. Permissive effect of the extracellular matrix on cell proliferation in vitro. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4094–4098. doi: 10.1073/pnas.77.7.4094. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Griffith T. M., Edwards D. H., Davies R. L., Harrison T. J., Evans K. T. EDRF coordinates the behaviour of vascular resistance vessels. Nature. 1987 Oct 1;329(6138):442–445. doi: 10.1038/329442a0. [DOI] [PubMed] [Google Scholar]
  8. Gruetter C. A., Barry B. K., McNamara D. B., Gruetter D. Y., Kadowitz P. J., Ignarro L. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J Cyclic Nucleotide Res. 1979;5(3):211–224. [PubMed] [Google Scholar]
  9. Gräser T., Leisner H., Tiedt N. Absence of role of endothelium in the response of isolated porcine coronary arteries to acetylcholine. Cardiovasc Res. 1986 Apr;20(4):299–302. doi: 10.1093/cvr/20.4.299. [DOI] [PubMed] [Google Scholar]
  10. Mulvany M. J., Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 1977 Jul;41(1):19–26. doi: 10.1161/01.res.41.1.19. [DOI] [PubMed] [Google Scholar]
  11. Rapoport R. M., Murad F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res. 1983 Mar;52(3):352–357. doi: 10.1161/01.res.52.3.352. [DOI] [PubMed] [Google Scholar]
  12. Shimokawa H., Lam J. Y., Chesebro J. H., Bowie E. J., Vanhoutte P. M. Effects of dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries. Circulation. 1987 Oct;76(4):898–905. doi: 10.1161/01.cir.76.4.898. [DOI] [PubMed] [Google Scholar]
  13. Srivastava K. C. Effects of dietary fatty acids, prostaglandins and related compounds on the role of platelets in thrombosis. Biochem Exp Biol. 1980;16(3):317–338. [PubMed] [Google Scholar]
  14. Vanhoutte P. M., Rubanyi G. M., Miller V. M., Houston D. S. Modulation of vascular smooth muscle contraction by the endothelium. Annu Rev Physiol. 1986;48:307–320. doi: 10.1146/annurev.ph.48.030186.001515. [DOI] [PubMed] [Google Scholar]

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