Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1988 Dec;95(4):1011–1013. doi: 10.1111/j.1476-5381.1988.tb11733.x

Induction of rat gastric damage by the endothelium-derived peptide, endothelin.

B J Whittle 1, J V Esplugues 1
PMCID: PMC1854285  PMID: 3064853

Abstract

The effect of the endogenous vasoconstrictor peptide, endothelin, on gastric mucosal integrity has been investigated in the rat. Local intra-arterial infusion of endothelin, in picomole doses, dose-dependently induced haemorrhagic and necrotic damage in the gastric mucosa. Such injury was not prevented by atropine, cimetidine, adrenoceptor antagonists, indomethacin, or the 5-lipoxygenase inhibitor BW A4C. These results suggest a potential pro-ulcerogenic role of endothelin in the pathogenesis of gastric damage and ulceration.

Full text

PDF
1011

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Esplugues J. V., Whittle B. J. Close-arterial administration of the thromboxane mimetic U-46619 induces damage to the rat gastric mucosa. Prostaglandins. 1988 Feb;35(2):137–148. doi: 10.1016/0090-6980(88)90082-2. [DOI] [PubMed] [Google Scholar]
  2. Esplugues J. V., Whittle B. J. Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat. Br J Pharmacol. 1988 Jan;93(1):222–228. doi: 10.1111/j.1476-5381.1988.tb11425.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Tateson J. E., Randall R. W., Reynolds C. H., Jackson W. P., Bhattacherjee P., Salmon J. A., Garland L. G. Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo. Br J Pharmacol. 1988 Jun;94(2):528–539. doi: 10.1111/j.1476-5381.1988.tb11557.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Whittle B. J., Kauffman G. L., Moncada S. Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa. Nature. 1981 Jul 30;292(5822):472–474. doi: 10.1038/292472a0. [DOI] [PubMed] [Google Scholar]
  5. Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yazaki Y., Goto K., Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988 Mar 31;332(6163):411–415. doi: 10.1038/332411a0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES