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. 1989 Apr;96(4):872–874. doi: 10.1111/j.1476-5381.1989.tb11897.x

Castor oil increases intestinal formation of platelet-activating factor and acid phosphatase release in the rat.

A Pinto 1, A Calignano 1, N Mascolo 1, G Autore 1, F Capasso 1
PMCID: PMC1854439  PMID: 2743081

Abstract

1. When castor oil was administered by gavage to rats, the duodenum and jejunum but not ileum and colon produced large amounts (5-6 fold greater than control) of platelet activating factor (Paf). 2. Intraluminal release of acid phosphatase (AP) was also markedly increased (5-6 fold greater than control) in the duodenum and jejunum of castor oil-treated rats and there was a correlation between the elevated release of AP and intestinal hyperaemia. 3. These findings support a role for Paf as a mediator of intestinal damage induced by castor oil.

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Selected References

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