Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1989 May;97(1):147–152. doi: 10.1111/j.1476-5381.1989.tb11935.x

Regional haemodynamic effect of vasopressin infusion in conscious, unrestrained, Brattleboro rats.

S M Gardiner 1, A M Compton 1, T Bennett 1
PMCID: PMC1854471  PMID: 2524234

Abstract

1. Incremental rates of infusion (0.027-4.0 pmol min-1) of exogenous vasopressin were given for 10 min periods to conscious, Brattleboro (i.e. vasopressin-deficient) rats, which had been chronically instrumented with pulsed Doppler probes and intravascular catheters (to permit assessment of regional haemodynamic changes). 2. There were no significant effects of the two lowest rates of infusion (0.027 and 0.105 pmol min-1) but, after 10 min of vasopressin infusion at 0.313 pmol min-1, superior mesenteric vasoconstriction had occurred unaccompanied by any other changes. Infusion of vasopressin at 0.687 pmol min-1 produced increases in blood pressure and in both mesenteric and hindquarters vascular resistance, but not change in renal vascular resistance or heart rate. These results do not indicate specific interactions between exogenous vasopressin and baroreflex mechanisms to offset the pressor effect of the neuropeptide. 3. The marked bradycardia, hypertension and renal, mesenteric and hindquarters vasoconstriction seen after 10 min infusion of vasopressin at 4.0 pmol min-1 were all abolished 10 min after administration of an antagonist of V1-receptors [+)-(CH2)5Tyr(Et)DAVP); additional antagonism of V2-receptors (with the non-selective antagonist (+)-(CH2)5Tyr(Et)VAVP) had no effects on any measured variable. Hence, the present experiments provide no evidence for important vasodilator effect of vasopressin in conscious, Brattleboro rats.

Full text

PDF
147

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett T., Gardiner S. M. Influence of exogenous vasopressin on baroreflex mechanisms. Clin Sci (Lond) 1986 Apr;70(4):307–315. doi: 10.1042/cs0700307. [DOI] [PubMed] [Google Scholar]
  2. Gardiner S. M., Bennett T. Cardiac baroreflex sensitivities in conscious, unrestrained, Long Evans and Brattleboro rats. J Auton Nerv Syst. 1988 Sep;23(3):213–219. doi: 10.1016/0165-1838(88)90096-3. [DOI] [PubMed] [Google Scholar]
  3. Gardiner S. M., Bennett T., Compton A. M. Regional haemodynamic effects of neuropeptide Y, vasopressin and angiotensin II in conscious, unrestrained, Long Evans and Brattleboro rats. J Auton Nerv Syst. 1988 Sep;24(1-2):15–27. doi: 10.1016/0165-1838(88)90131-2. [DOI] [PubMed] [Google Scholar]
  4. Gardiner S. M., Bennett T. Endogenous vasopressin and baroreflex mechanisms. Brain Res. 1986 Dec;396(4):317–334. doi: 10.1016/0165-0173(86)90003-2. [DOI] [PubMed] [Google Scholar]
  5. Gardiner S. M., Bennett T. The control of heart rate in rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain). Ann N Y Acad Sci. 1982;394:363–374. doi: 10.1111/j.1749-6632.1982.tb37447.x. [DOI] [PubMed] [Google Scholar]
  6. Gardiner S. M., Compton A. M., Bennett T. Regional haemodynamic effects of depressor neuropeptides in conscious, unrestrained, Long Evans and Brattleboro rats. Br J Pharmacol. 1988 Sep;95(1):197–208. doi: 10.1111/j.1476-5381.1988.tb16565.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Haywood J. R., Shaffer R. A., Fastenow C., Fink G. D., Brody M. J. Regional blood flow measurement with pulsed Doppler flowmeter in conscious rat. Am J Physiol. 1981 Aug;241(2):H273–H278. doi: 10.1152/ajpheart.1981.241.2.H273. [DOI] [PubMed] [Google Scholar]
  8. Hofbauer K. G., Dienemann H., Forgiarini P., Stalder R., Wood J. M. Renal vascular effects of angiotensin II, arginine-vasopressin and bradykinin in rats: interactions with prostaglandins. Gen Pharmacol. 1983;14(1):145–147. doi: 10.1016/0306-3623(83)90086-1. [DOI] [PubMed] [Google Scholar]
  9. Imai Y., Nolan P. L., Johnston C. I. Restoration of suppressed baroreflex sensitivity in rats with hereditary diabetes insipidus (Brattleboro rats) by arginine-vasopressin and DDAVP. Circ Res. 1983 Aug;53(2):140–149. doi: 10.1161/01.res.53.2.140. [DOI] [PubMed] [Google Scholar]
  10. Liard J. F. Characterization of acute hemodynamic effects of antidiuretic agonists in conscious dogs. J Cardiovasc Pharmacol. 1988 Feb;11(2):174–180. [PubMed] [Google Scholar]
  11. Theodorsson-Norheim E. Friedman and Quade tests: BASIC computer program to perform nonparametric two-way analysis of variance and multiple comparisons on ranks of several related samples. Comput Biol Med. 1987;17(2):85–99. doi: 10.1016/0010-4825(87)90003-5. [DOI] [PubMed] [Google Scholar]
  12. Walker B. R., Brizzee B. L., Harrison-Bernard L. M. Potentiated vasoconstrictor response to vasopressin following meclofenamate in conscious rats. Proc Soc Exp Biol Med. 1988 Feb;187(2):157–164. doi: 10.3181/00379727-187-42649. [DOI] [PubMed] [Google Scholar]
  13. Walker B. R. Evidence for a vasodilatory effect of vasopressin in the conscious rat. Am J Physiol. 1986 Jul;251(1 Pt 2):H34–H39. doi: 10.1152/ajpheart.1986.251.1.H34. [DOI] [PubMed] [Google Scholar]
  14. Webb R. L., Osborn J. W., Jr, Cowley A. W., Jr Cardiovascular actions of vasopressin: baroreflex modulation in the conscious rat. Am J Physiol. 1986 Dec;251(6 Pt 2):H1244–H1251. doi: 10.1152/ajpheart.1986.251.6.H1244. [DOI] [PubMed] [Google Scholar]
  15. Woods R. L., Johnston C. I. Contribution of vasopressin to the maintenance of blood pressure during dehydration. Am J Physiol. 1983 Nov;245(5 Pt 1):F615–F621. doi: 10.1152/ajprenal.1983.245.5.F615. [DOI] [PubMed] [Google Scholar]
  16. Wright C. E., Angus J. A., Korner P. I. Vascular amplifier properties in renovascular hypertension in conscious rabbits. Hindquarter responses to constrictor and dilator stimuli. Hypertension. 1987 Feb;9(2):122–131. doi: 10.1161/01.hyp.9.2.122. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES