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. 1989 Jun;97(2):483–489. doi: 10.1111/j.1476-5381.1989.tb11976.x

M-octopamine injected into the paraventricular nucleus induces eating in rats: a comparison with noradrenaline-induced eating.

P J Fletcher 1, I A Paterson 1
PMCID: PMC1854508  PMID: 2503224

Abstract

1. The effects on food intake in rats of injection of m- and p-octopamine into the paraventricular nucleus (PVN) of the hypothalamus were examined, and compared to the effects of noradrenaline (NA). 2. m-Octopamine injected into the PVN induced a dose-dependent increase in food intake, with the maximal effect occurring at a dose of 25 nmol. p-Octopamine did not elicit eating unless it was administered to animals pretreated with the monoamine oxidase inhibitor, pargyline. 3. The effects of pretreatment with various adrenoceptor antagonists, injected into the PVN, on the eating responses induced by 25 nmol m-octopamine and NA were examined. The alpha 1-adrenoceptor antagonist, corynanthine, and the beta-adrenoceptor antagonist, propranolol, failed to alter the eating induced by m-octopamine or NA. The effects of these two amines were susceptible to blockade of alpha 2-adrenoceptors. Idazoxan reversed the eating induced by m-octopamine and noradrenaline. However, yohimbine was effective only against the eating induced by m-octopamine. Thus, both m-octopamine and NA appear to act via alpha 2, but not alpha 1 or beta-adrenoceptors. 4. Injection of alpha-methyl-p-tyrosine into the PVN attenuated the effect of m-octopamine, but not of NA. This result suggests that m-octopamine elicits eating, at least in part, by releasing endogenous NA. 5. The NA and octopamine uptake inhibitor, desipramine, significantly potentiated the eating induced by a low dose of m-octopamine. This effect may occur because desipramine would prolong the synaptic activity of released NA. 6. The results indicate that m-octopamine elicits a marked and reliable eating response which is mediated largely by a release of endogenous NA, which acts at alpha 2-receptors. These results are consistent with the view that octopamine may function as a modulator of NA activity in the central nervous system.

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Selected References

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  1. Axelrod J., Saavedra J. M. Octopamine. Nature. 1977 Feb 10;265(5594):501–504. doi: 10.1038/265501a0. [DOI] [PubMed] [Google Scholar]
  2. Baldessarini R. J., Vogt M. The uptake and subcellular distribution of aromatic amines in the brain of the rat. J Neurochem. 1971 Dec;18(12):2519–2533. doi: 10.1111/j.1471-4159.1971.tb00208.x. [DOI] [PubMed] [Google Scholar]
  3. Booth D. A. Mechanism of action of norepinephrine in eliciting an eating response on injection into the rat hypothalamus. J Pharmacol Exp Ther. 1968 Apr;160(2):336–348. [PubMed] [Google Scholar]
  4. Brown C. M., McGrath J. C., Midgley J. M., Muir A. G., O'Brien J. W., Thonoor C. M., Williams C. M., Wilson V. G. Activities of octopamine and synephrine stereoisomers on alpha-adrenoceptors. Br J Pharmacol. 1988 Feb;93(2):417–429. doi: 10.1111/j.1476-5381.1988.tb11449.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Buck S. H., Murphy R. C., Molinoff P. B. The normal occurrence of octopamine in the central nervous system of the rat. Brain Res. 1977 Feb 18;122(2):281–297. doi: 10.1016/0006-8993(77)90295-5. [DOI] [PubMed] [Google Scholar]
  6. Celuch S. M., Juorio A. V. Effects of deuterium substitution on the chronotropic responses to some sympathomimetic amines in the isolated rat atria. Naunyn Schmiedebergs Arch Pharmacol. 1987 Oct;336(4):391–395. doi: 10.1007/BF00164871. [DOI] [PubMed] [Google Scholar]
  7. Danielson T. J., Boulton A. A., Robertson H. A. m-Octopamine, p-octopamine and phenylethanolamine in rat brain: a sensitive, specific assay and the effects of some drugs. J Neurochem. 1977 Dec;29(6):1131–1135. doi: 10.1111/j.1471-4159.1977.tb06519.x. [DOI] [PubMed] [Google Scholar]
  8. Dao W. P., Walker R. J. Octopamine responses of neurones in the rat thalamus [proceedings]. Br J Pharmacol. 1980 Jan;68(1):132P–132P. [PMC free article] [PubMed] [Google Scholar]
  9. David J. C., Coulon J. F. Octopamine in invertebrates and vertebrates. A review. Prog Neurobiol. 1985;24(2):141–185. doi: 10.1016/0301-0082(85)90009-7. [DOI] [PubMed] [Google Scholar]
  10. David J. C., Delacour J. Brain contents of phenylethanolamine, m-octopamine and p-octopamine in the Roman strains of rats. Brain Res. 1980 Aug 11;195(1):231–235. doi: 10.1016/0006-8993(80)90882-3. [DOI] [PubMed] [Google Scholar]
  11. Delacour J., Coulon J. F., David J. C., Guenaire C. Brain octopamine and strain differences in avoidance behavior. Brain Res. 1983 Dec 12;288(1-2):169–176. doi: 10.1016/0006-8993(83)90091-4. [DOI] [PubMed] [Google Scholar]
  12. Fregly M. J., Kelleher D. L., Williams C. M. Adrenergic activity of ortho-, meta-, and para-octopamine. Pharmacology. 1979;18(4):180–187. doi: 10.1159/000137250. [DOI] [PubMed] [Google Scholar]
  13. Fregly M. J., Rowland N. E., Williams C. M., Greenleaf J. E. Effect of intracerebroventricularly administered octopamines and synephrines on angiotensin II-induced water intake in rats. Brain Res Bull. 1984 Aug;13(2):293–297. doi: 10.1016/0361-9230(84)90130-8. [DOI] [PubMed] [Google Scholar]
  14. Goldman C. K., Marino L., Leibowitz S. F. Postsynaptic alpha 2-noradrenergic receptors mediate feeding induced by paraventricular nucleus injection of norepinephrine and clonidine. Eur J Pharmacol. 1985 Sep 10;115(1):11–19. doi: 10.1016/0014-2999(85)90578-3. [DOI] [PubMed] [Google Scholar]
  15. Harmar A. J., Horn A. S. Octopamine in mammalian brain: rapid post mortem increase and effects of drugs. J Neurochem. 1976 May;26(5):987–993. doi: 10.1111/j.1471-4159.1976.tb06482.x. [DOI] [PubMed] [Google Scholar]
  16. Hicks T. P., McLennan H. Actions of octopamine upon dorsal horn neurones of the spinal cord. Brain Res. 1978 Nov 24;157(2):402–406. doi: 10.1016/0006-8993(78)90050-1. [DOI] [PubMed] [Google Scholar]
  17. Hicks T. P., McLennan H. Comparison of the actions of octopamine and catecholamines on single neurones of the rat cerebral cortex. Br J Pharmacol. 1978 Dec;64(4):485–491. doi: 10.1111/j.1476-5381.1978.tb17309.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Ibrahim K. E., Couch M. W., Williams C. M., Fregly M. J., Midgley J. M. m-Octopamine: normal occurrence with p-octopamine in mammalian sympathetic nerves. J Neurochem. 1985 Jun;44(6):1862–1867. doi: 10.1111/j.1471-4159.1985.tb07180.x. [DOI] [PubMed] [Google Scholar]
  19. Jones R. S. Noradrenaline-octopamine interactions on cortical neurones in the rat. Eur J Pharmacol. 1982 Jan 22;77(2-3):159–162. doi: 10.1016/0014-2999(82)90012-7. [DOI] [PubMed] [Google Scholar]
  20. Jordan R., Midgley J. M., Thonoor C. M., Williams C. M. Beta-adrenergic activities of octopamine and synephrine stereoisomers on guinea-pig atria and trachea. J Pharm Pharmacol. 1987 Sep;39(9):752–754. doi: 10.1111/j.2042-7158.1987.tb06986.x. [DOI] [PubMed] [Google Scholar]
  21. KOPIN I. J., FISCHER J. E., MUSACCHIO J. M., HORST W. D., WEISE V. K. "FALSE NEUROCHEMICAL TRANSMITTERS" AND THE MECHANISM OF SYMPATHETIC BLOCKADE BY MONOAMINE OXIDASE INHIBITORS. J Pharmacol Exp Ther. 1965 Feb;147:186–193. [PubMed] [Google Scholar]
  22. Leibowitz S. F. Paraventricular nucleus: a primary site mediating adrenergic stimulation of feeding and drinking. Pharmacol Biochem Behav. 1978 Feb;8(2):163–175. doi: 10.1016/0091-3057(78)90333-7. [DOI] [PubMed] [Google Scholar]
  23. Molinoff P. B., Axelrod J. Distribution and turnover of octopamine in tissues. J Neurochem. 1972 Jan;19(1):157–163. doi: 10.1111/j.1471-4159.1972.tb01265.x. [DOI] [PubMed] [Google Scholar]
  24. Molinoff P., Axelrod J. Octopamine: normal occurrence in sympathetic nerves of rats. Science. 1969 Apr 25;164(3878):428–429. doi: 10.1126/science.164.3878.428. [DOI] [PubMed] [Google Scholar]
  25. Reimann W. Evidence for neuronal uptake and release of norfenefrine and evaluation of its alpha-agonistic effects in the rabbit pulmonary artery. Arzneimittelforschung. 1984;34(5):575–578. [PubMed] [Google Scholar]
  26. Robertson H. A., Juorio A. V. Octopamine and some related noncatecholic amines in invertebrate nervous systems. Int Rev Neurobiol. 1976;19:173–224. doi: 10.1016/s0074-7742(08)60704-7. [DOI] [PubMed] [Google Scholar]
  27. Williams C. M., Couch M. W., Thonoor C. M., Midgley J. M. Isomeric octopamines: their occurrence and functions. J Pharm Pharmacol. 1987 Mar;39(3):153–157. doi: 10.1111/j.2042-7158.1987.tb06240.x. [DOI] [PubMed] [Google Scholar]

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