Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1984 Jan;25(1):134–136. doi: 10.1128/aac.25.1.134

Antibacterial properties of tuftsin and its analogs.

D Blok-Perkowska, F Muzalewski, D Konopińska
PMCID: PMC185452  PMID: 6703677

Abstract

The antibacterial properties of tuftsin and its 11 analogs on 20 bacterial strains were investigated. Tuftsin showed a definite antibacterial effect at a minimal effective concentration of 62.5 micrograms/ml. All analogs were either less effective or lacked any activity. The bacteria used included some highly pathogenic organisms.

Full text

PDF
134

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cegielska A., Dabrowska M., Lammek B., Maćkiewicz Z., Taylor A., Kupryszewski G. Antibacterial peptide derivatives. Part VI. Derivatives of the L-lysine and L-ornithine dipeptides and their effect on the morphology of bacterial cells. Mater Med Pol. 1979 Oct-Dec;11(4):324–329. [PubMed] [Google Scholar]
  2. Dabrowska M., Kupryszewski G., Muzalewski F., Kochanowski J. Derivatives of the L-lysine-peptides with antibacterial activity. Pol J Pharmacol Pharm. 1976 Jan-Feb;28(1):77–88. [PubMed] [Google Scholar]
  3. Fridkin M., Gottlieb P. Tuftsin, Thr-Lys-Pro-Arg. Anatomy of an immunologically active peptide. Mol Cell Biochem. 1981 Dec 4;41:73–97. doi: 10.1007/BF00225299. [DOI] [PubMed] [Google Scholar]
  4. Konopínska D., Nawrocka E., Siemion I. Z., Slopek S., Szymaniec S., Klonowska E. Partial sequences of histones with tuftsin activity. Int J Pept Protein Res. 1977 Jan;9(1):71–77. doi: 10.1111/j.1399-3011.1977.tb01839.x. [DOI] [PubMed] [Google Scholar]
  5. Kurihara T., Ito H., Tsutida Y. [Studies on antibacterial peptide. XIV. Synthesis and antibacterial activity of alpha-acylpentapeptide related to colistin. III (author's transl)]. Yakugaku Zasshi. 1981 Apr;101(4):349–353. doi: 10.1248/yakushi1947.101.4_349. [DOI] [PubMed] [Google Scholar]
  6. Najjar V. A. The clinical and physiological aspects of tuftsin deficiency syndromes exhibiting defective phagocytosis. Klin Wochenschr. 1979 Aug 1;57(15):751–756. doi: 10.1007/BF01478032. [DOI] [PubMed] [Google Scholar]
  7. Najjar V. A. The physiological role of gamma-globulin. Adv Enzymol Relat Areas Mol Biol. 1974;41(0):129–178. doi: 10.1002/9780470122860.ch4. [DOI] [PubMed] [Google Scholar]
  8. Nishioka K., Constantopoulos A., Sato P. S., Mitchell W. M., Najjar V. A. Characteristics and isolation of the phagocytosis-stimulating peptide, tuftsin. Biochim Biophys Acta. 1973 May 17;310(1):217–229. doi: 10.1016/0005-2795(73)90024-x. [DOI] [PubMed] [Google Scholar]
  9. Nishioka K., Sato P. S., Constantopoulos A., Najjar V. A. The chemical synthesis of the phagocytosis-stimulating tetrapeptide tuftsin (Thr-Lys-Pro-Arg) and its biological properties. Biochim Biophys Acta. 1973 May 17;310(1):230–237. doi: 10.1016/0005-2795(73)90025-1. [DOI] [PubMed] [Google Scholar]
  10. Siemion I. Z., Konopinska D. Tuftsin analogs and their biological activity. Mol Cell Biochem. 1981 Dec 4;41:99–112. doi: 10.1007/BF00225300. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES