Abstract
The concentrations of cefotiam dihydrochloride (CTM) in maternal and fetal blood and in amniotic fluid were determined by bioassay in 38 women at parturition. With an intravenous infusion of 1 g of CTM, the decline in concentration of CTM in maternal blood was biphasic; CTM was not detectable at 6 h after administration. Peak levels of CTM in umbilical cord blood (13.0 to 23.9 micrograms/ml) were attained between 15 and 28 min after intravenous infusion; those in amniotic fluid (19.6 to 23.5 micrograms/ml) were attained at ca. 2.5 h.
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Selected References
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- Bray R. E., Boe R. W., Johnson W. L. Transfer of ampicillin into fetus and amniotic fluid from maternal plasma in late pregnancy. Am J Obstet Gynecol. 1966 Dec 1;96(7):938–942. doi: 10.1016/0002-9378(66)90438-8. [DOI] [PubMed] [Google Scholar]
- Craft I., Mullinger B. M., Kennedy M. R. Placental transfer of cefuroxime. Br J Obstet Gynaecol. 1981 Feb;88(2):141–145. doi: 10.1111/j.1471-0528.1981.tb00958.x. [DOI] [PubMed] [Google Scholar]
- Flaherty J. F., Boswell G. W., Winkel C. A., Elliott J. P. Pharmacokinetics of cefoxitin in patients at term gestation: lavage versus intravenous administration. Am J Obstet Gynecol. 1983 Aug 1;146(7):760–766. doi: 10.1016/0002-9378(83)91073-6. [DOI] [PubMed] [Google Scholar]
- MacAulay M. A., Abou-Sabe M., Charles D. Placental transfer of ampicillin. Am J Obstet Gynecol. 1966 Dec 1;96(7):943–950. doi: 10.1016/0002-9378(66)90439-x. [DOI] [PubMed] [Google Scholar]
- Miyakawa I., Taniyama K., Inoue H., Lee H. C., Mori N. Placental transfer of disodium sulbenicillin. Antimicrob Agents Chemother. 1982 May;21(5):838–839. doi: 10.1128/aac.21.5.838. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seeds A. E. Current concepts of amniotic fluid dynamics. Am J Obstet Gynecol. 1980 Nov 1;138(5):575–586. doi: 10.1016/0002-9378(80)90289-6. [DOI] [PubMed] [Google Scholar]