Abstract
Removal of venous endothelium in man leads to vasoconstriction and loss of dilator response to acetylcholine but not to glyceryl trinitrate. This pattern of responses can be accounted for by loss of endothelium-derived relaxing factor (EDRF), but not by loss of prostacyclin. This provides the first direct evidence for endothelium-dependent dilatation in man in vivo, and suggests that basal release of EDRF is a determinant of resting venous tone.
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Selected References
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- Bolton T. B., Lang R. J., Takewaki T. Mechanisms of action of noradrenaline and carbachol on smooth muscle of guinea-pig anterior mesenteric artery. J Physiol. 1984 Jun;351:549–572. doi: 10.1113/jphysiol.1984.sp015262. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Furchgott R. F., Zawadzki J. V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980 Nov 27;288(5789):373–376. doi: 10.1038/288373a0. [DOI] [PubMed] [Google Scholar]
- Hayashi Y., Tomoike H., Nagasawa K., Yamada A., Nishijima H., Adachi H., Nakamura M. Functional and anatomical recovery of endothelium after denudation of coronary artery. Am J Physiol. 1988 Jun;254(6 Pt 2):H1081–H1090. doi: 10.1152/ajpheart.1988.254.6.H1081. [DOI] [PubMed] [Google Scholar]
- Lam J. Y., Chesebro J. H., Fuster V. Platelets, vasoconstriction, and nitroglycerin during arterial wall injury. A new antithrombotic role for an old drug. Circulation. 1988 Sep;78(3):712–716. doi: 10.1161/01.cir.78.3.712. [DOI] [PubMed] [Google Scholar]
- Moncada S., Herman A. G., Higgs E. A., Vane J. R. Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium. Thromb Res. 1977 Sep;11(3):323–344. doi: 10.1016/0049-3848(77)90185-2. [DOI] [PubMed] [Google Scholar]
- Nachev C., Collier J., Robinson B. Simplified method for measuring compliance of superficial veins. Cardiovasc Res. 1971 Jan;5(1):147–156. doi: 10.1093/cvr/5.1.147. [DOI] [PubMed] [Google Scholar]
- Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yazaki Y., Goto K., Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988 Mar 31;332(6163):411–415. doi: 10.1038/332411a0. [DOI] [PubMed] [Google Scholar]