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. 1989 Aug;97(4):1027–1030. doi: 10.1111/j.1476-5381.1989.tb12558.x

The effect of atrial natriuretic peptide on human isolated resistance arteries.

A D Hughes 1, H Nielsen 1, P S Sever 1
PMCID: PMC1854616  PMID: 2529013

Abstract

1. The action of (1-28) alpha-human atrial natriuretic peptide (ANP) was studied on human isolated resistance arteries. 2. Renal, skeletal muscle, omental and subcutaneous resistance arteries were taken from tissue removed at surgery and isometric tension responses were measured with a myograph. 3. ANP (10(-9)-10(-6) M) relaxed precontracted segments of renal and skeletal muscle arteries in a concentration-dependent manner. ANP failed to relax isolated omental or subcutaneous arteries. 4. The effect of ANP on human isolated resistance arteries varies depending on the site of origin of the artery.

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Selected References

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  1. Aalkjaer C., Mulvany M. J. Functional and morphological properties of human omental resistance vessels. Blood Vessels. 1981;18(6):233–244. doi: 10.1159/000158357. [DOI] [PubMed] [Google Scholar]
  2. Aalkjaer C., Mulvany M. J., Nyborg N. C. Atrial natriuretic factor causes specific relaxation of rat renal arcuate arteries. Br J Pharmacol. 1985 Oct;86(2):447–453. doi: 10.1111/j.1476-5381.1985.tb08914.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Altura B. M. Neurohypophyseal hormones and analogues: rat pressor potency versus contractile potency on rat arterioles and arteries. Proc Soc Exp Biol Med. 1974 Sep;146(4):1054–1060. doi: 10.3181/00379727-146-38245. [DOI] [PubMed] [Google Scholar]
  4. Anderson J. V., Donckier J., McKenna W. J., Bloom S. R. The plasma release of atrial natriuretic peptide in man. Clin Sci (Lond) 1986 Aug;71(2):151–155. doi: 10.1042/cs0710151. [DOI] [PubMed] [Google Scholar]
  5. Anderson J., Struthers A., Christofides N., Bloom S. Atrial natriuretic peptide: an endogenous factor enhancing sodium excretion in man. Clin Sci (Lond) 1986 Apr;70(4):327–331. doi: 10.1042/cs0700327. [DOI] [PubMed] [Google Scholar]
  6. Bolli P., Müller F. B., Linder L., Raine A. E., Resink T. J., Erne P., Kiowski W., Ritz R., Bühler F. R. The vasodilator potency of atrial natriuretic peptide in man. Circulation. 1987 Jan;75(1):221–228. doi: 10.1161/01.cir.75.1.221. [DOI] [PubMed] [Google Scholar]
  7. Bussien J. P., Biollaz J., Waeber B., Nussberger J., Turini G. A., Brunner H. R., Brunner-Ferber F., Gomez H. J., Otterbein E. S. Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers. J Cardiovasc Pharmacol. 1986 Jan-Feb;8(1):216–220. doi: 10.1097/00005344-198601000-00031. [DOI] [PubMed] [Google Scholar]
  8. Cauvin C., Tejerina M., van Breemen C. Effects of atriopeptin III on isolated mesenteric resistance vessels from SHR and WKY. Am J Physiol. 1987 Dec;253(6 Pt 2):H1612–H1617. doi: 10.1152/ajpheart.1987.253.6.H1612. [DOI] [PubMed] [Google Scholar]
  9. Donald D. E., Shepherd J. T. Reflexes from the heart and lungs: physiological curiosities or important regulatory mechanisms. Cardiovasc Res. 1978 Aug;12(8):446–469. [PubMed] [Google Scholar]
  10. Edwards R. M., Weidley E. F. Lack of effect of atriopeptin II on rabbit glomerular arterioles in vitro. Am J Physiol. 1987 Feb;252(2 Pt 2):F317–F321. doi: 10.1152/ajprenal.1987.252.2.F317. [DOI] [PubMed] [Google Scholar]
  11. HADDY F. J. Peripheral vascular resistance. Am Heart J. 1960 Jul;60:1–5. doi: 10.1016/0002-8703(60)90054-5. [DOI] [PubMed] [Google Scholar]
  12. Hughes A., Thom S., Goldberg P., Martin G., Sever P. Direct effect of alpha-human atrial natriuretic peptide on human vasculature in vivo and in vitro. Clin Sci (Lond) 1988 Feb;74(2):207–211. doi: 10.1042/cs0740207. [DOI] [PubMed] [Google Scholar]
  13. Kangawa K., Matsuo H. Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP). Biochem Biophys Res Commun. 1984 Jan 13;118(1):131–139. doi: 10.1016/0006-291x(84)91077-5. [DOI] [PubMed] [Google Scholar]
  14. Mulvany M. J. Do resistance vessel abnormalities contribute to the elevated blood pressure of spontaneously-hypertensive rats? A review of some of the evidence. Blood Vessels. 1983;20(1):1–22. doi: 10.1159/000158455. [DOI] [PubMed] [Google Scholar]
  15. Mulvany M. J., Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 1977 Jul;41(1):19–26. doi: 10.1161/01.res.41.1.19. [DOI] [PubMed] [Google Scholar]
  16. Mulvany M. J., Halpern W. Mechanical properties of vascular smooth muscle cells in situ. Nature. 1976 Apr 15;260(5552):617–619. doi: 10.1038/260617a0. [DOI] [PubMed] [Google Scholar]
  17. Needleman P., Adams S. P., Cole B. R., Currie M. G., Geller D. M., Michener M. L., Saper C. B., Schwartz D., Standaert D. G. Atriopeptins as cardiac hormones. Hypertension. 1985 Jul-Aug;7(4):469–482. doi: 10.1161/01.hyp.7.4.469. [DOI] [PubMed] [Google Scholar]
  18. Ogihara T., Shima J., Hara H., Kumahara Y., Kangawa K., Matsuo H. Changes in human plasma atrial natriuretic polypeptide concentration in normal subjects during passive leg raising and whole-body tilting. Clin Sci (Lond) 1986 Aug;71(2):147–150. doi: 10.1042/cs0710147. [DOI] [PubMed] [Google Scholar]
  19. Osol G., Halpern W., Tesfamariam B., Nakayama K., Weinberg D. Synthetic atrial natriuretic factor does not dilate resistance-sized arteries. Hypertension. 1986 Jul;8(7):606–610. doi: 10.1161/01.hyp.8.7.606. [DOI] [PubMed] [Google Scholar]
  20. Rapoport R. M., Ginsburg R., Waldman S. A., Murad F. Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro. Eur J Pharmacol. 1986 May 13;124(1-2):193–196. doi: 10.1016/0014-2999(86)90144-5. [DOI] [PubMed] [Google Scholar]
  21. Richards A. M., Nicholls M. G., Ikram H., Webster M. W., Yandle T. G., Espiner E. A. Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers. Lancet. 1985 Mar 9;1(8428):545–549. doi: 10.1016/s0140-6736(85)91207-3. [DOI] [PubMed] [Google Scholar]
  22. Theiss G., John A., Morich F., Neuser D., Schröder W., Stasch J. P., Wohlfeil S. Alpha-h-ANP is the only form of circulating ANP in humans. FEBS Lett. 1987 Jun 22;218(1):159–162. doi: 10.1016/0014-5793(87)81038-4. [DOI] [PubMed] [Google Scholar]
  23. Winquist R. J., Faison E. P., Waldman S. A., Schwartz K., Murad F., Rapoport R. M. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7661–7664. doi: 10.1073/pnas.81.23.7661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Winquist R. J. The relaxant effects of atrial natriuretic factor on vascular smooth muscle. Life Sci. 1985 Sep 23;37(12):1081–1087. doi: 10.1016/0024-3205(85)90351-0. [DOI] [PubMed] [Google Scholar]

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