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. 1984 Feb;25(2):165–167. doi: 10.1128/aac.25.2.165

In vitro susceptibility of Nocardia asteroides to 25 antimicrobial agents.

D H Dewsnup, D N Wright
PMCID: PMC185466  PMID: 6370125

Abstract

Fifty-two clinical isolates of Nocardia asteroides were tested by agar dilution for their susceptibility to 25 antimicrobial agents. In general, susceptibility could not be predicted based on the antibiotic class tested. However, the beta-lactams, including third-generation cephalosporins, were generally ineffective (MIC for 90% of the organisms [MIC90], between 64 and greater than 256 micrograms/ml), whereas minocycline and doxycycline were generally effective (MIC90, 4 and 8 micrograms/ml, respectively). Cycloserine was not effective below 60 micrograms/ml. The MIC50 and MIC90 of sulfamethoxazole was 16 and 32 micrograms/ml, respectively, and that of trimethoprim varied widely (16 and greater than 256 micrograms/ml, respectively). Based on MIC90 data, only doxycycline, minocycline, sulfamethoxazole, and imipenem could be applied empirically.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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