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. 1989 Sep;98(1):236–242. doi: 10.1111/j.1476-5381.1989.tb16887.x

Opposite central and peripheral control by endogenous opioids of intestinal motility in fed rats.

P J Rivière 1, M Liberge 1, D Murillo-Lopez 1, L Bueno 1
PMCID: PMC1854664  PMID: 2679957

Abstract

1. The effects of the inhibitors of endopeptidase EC 24.11, thiorphan and phosphoramidon administered i.c.v. (40 micrograms kg-1) i.p. (400 micrograms kg-1), or orally (400 micrograms kg-1), on intestinal motor activity in fed rats was compared to the effects of similar doses of the angiotensin converting enzyme inhibitor, captopril and the synthetic enkephalin analogue [D-Ala2 Met5] enkephalinamide (Dalamide). Drugs were administered alone or after pretreatment with naloxone or N-methyl levallorphan (300 micrograms kg-1, i.p.) given 10 min prior to gavage with a standard meal. 2. In control conditions, in the duodenum, the disruption of the migrating myoelectric complex (MMC) by gavage with a standard meal lasted between 105.6 and 119.1 min. This duration was significantly decreased by thiorphan (60.3 +/- 15.0 min), phosphoramidon (67.9 +/- 7.3 min), captopril (26.3 +/- 10.2 min) and Dalamide (42.4 +/- 9.6 min), administered i.c.v. 3. In contrast, after the i.p. administration of thiorphan, phosphoramidon and Dalamide the delay in the return of the MMC pattern was increased. Such an effect was also seen after the oral administration of phosphoramidon or Dalamide. Neither i.p. nor oral captopril administration altered the duration of postprandial pattern. 4. A prior treatment with naloxone i.p. (300 micrograms kg-1) that had no effect per se, antagonized the effect produced by i.c.v. administration of thiorphan, phosphoramidon or Dalamide, but failed to reverse the effect of captopril.(ABSTRACT TRUNCATED AT 250 WORDS)

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Selected References

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  1. Bueno L., Ferre J. P., Fioramonti J., Honde C. Effects of intracerebroventricular administration of neurotensin, substance P and calcitonin on gastrointestinal motility in normal and vagotomized rats. Regul Pept. 1983 Jul;6(3):197–205. doi: 10.1016/0167-0115(83)90138-6. [DOI] [PubMed] [Google Scholar]
  2. Bueno L., Fioramonti J. Action of opiates on gastrointestinal function. Baillieres Clin Gastroenterol. 1988 Jan;2(1):123–139. doi: 10.1016/0950-3528(88)90024-3. [DOI] [PubMed] [Google Scholar]
  3. Bueno L., Fioramonti J., Hondé C., Fargeas M. J., Primi M. P. Central and peripheral control of gastrointestinal and colonic motility by endogenous opiates in conscious dogs. Gastroenterology. 1985 Feb;88(2):549–556. doi: 10.1016/0016-5085(85)90520-7. [DOI] [PubMed] [Google Scholar]
  4. Bueno L., Fioramonti J., Ruckebusch Y. Rate of flow of digesta and electrical activity of the small intestine in dogs and sheep. J Physiol. 1975 Jul;249(1):69–85. doi: 10.1113/jphysiol.1975.sp011003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bueno L., Ruckebusch Y. Origine centrale de l'action excito-motrice de l'intestin par la morphine. C R Seances Soc Biol Fil. 1978;172(5):972–977. [PubMed] [Google Scholar]
  6. Coquerel A., Dubuc I., Menard J. F., Kitabgi P., Costentin J. Naloxone-insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan. Brain Res. 1986 Nov 29;398(2):386–389. doi: 10.1016/0006-8993(86)91501-5. [DOI] [PubMed] [Google Scholar]
  7. Deschodt-Lanckman M., Strosberg A. D. In vitro degradation of the C-terminal octapeptide of cholecystokinin by 'enkephalinase A'. FEBS Lett. 1983 Feb 7;152(1):109–113. doi: 10.1016/0014-5793(83)80493-1. [DOI] [PubMed] [Google Scholar]
  8. Fioramonti J., Fargeas M. J., Bueno L. Stimulation of gastrointestinal motility by loperamide in dogs. Dig Dis Sci. 1987 Jun;32(6):641–646. doi: 10.1007/BF01296165. [DOI] [PubMed] [Google Scholar]
  9. Galambos J. T., Hersh T., Schroder S., Wenger J. Loperamide: a new antidiarrheal agent in the treatment of chronic diarrhea. Gastroenterology. 1976 Jun;70(6):1026–1029. [PubMed] [Google Scholar]
  10. Galligan J. J., Burks T. F. Centrally mediated inhibition of small intestinal transit and motility by morphine in the rat. J Pharmacol Exp Ther. 1983 Aug;226(2):356–361. [PubMed] [Google Scholar]
  11. Garcia R., Thibault G., Seidah N. G., Lazure C., Cantin M., Genest J., Chrétien M. Structure-activity relationships of atrial natriuretic factor (ANF). II. Effect of chain-length modifications on vascular reactivity. Biochem Biophys Res Commun. 1985 Jan 16;126(1):178–184. doi: 10.1016/0006-291x(85)90588-1. [DOI] [PubMed] [Google Scholar]
  12. Liberge M., Rivière P. M., Buéno L. Influence of enkephalinase inhibitors on gastric emptying in mice depends on the nature of the meal. Life Sci. 1988;42(21):2047–2053. doi: 10.1016/0024-3205(88)90117-8. [DOI] [PubMed] [Google Scholar]
  13. Manara L., Bianchetti A. The central and peripheral influences of opioids on gastrointestinal propulsion. Annu Rev Pharmacol Toxicol. 1985;25:249–273. doi: 10.1146/annurev.pa.25.040185.001341. [DOI] [PubMed] [Google Scholar]
  14. Polak J. M., Bloom S. R., Sullivan S. N., Facer P., Pearse A. G. Enkephalin-like immunoreactivity in the human gastrointestinal tract. Lancet. 1977 May 7;1(8019):972–974. doi: 10.1016/s0140-6736(77)92277-2. [DOI] [PubMed] [Google Scholar]
  15. Rapoport S. I., Klee W. A., Pettigrew K. D., Ohno K. Entry of opioid peptides into the central nervous system. Science. 1980 Jan 4;207(4426):84–86. doi: 10.1126/science.7350645. [DOI] [PubMed] [Google Scholar]
  16. Roques B. P., Fournié-Zaluski M. C., Soroca E., Lecomte J. M., Malfroy B., Llorens C., Schwartz J. C. The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice. Nature. 1980 Nov 20;288(5788):286–288. doi: 10.1038/288286a0. [DOI] [PubMed] [Google Scholar]
  17. Rukebusch M., Fioramonti J. Electrical spiking activity and propulsion in small intestine in fed and fasted rats. Gastroenterology. 1975 Jun;68(6):1500–1508. [PubMed] [Google Scholar]
  18. Schulz R., Wüster M., Herz A. Centrally and peripherally mediated inhibition of intestinal motility by opioids. Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep;308(3):255–260. doi: 10.1007/BF00501390. [DOI] [PubMed] [Google Scholar]
  19. Schwartz J. C., Malfroy B., De La Baume S. Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase ("enkephalinase") as neuropeptidase. Life Sci. 1981 Oct 26;29(17):1715–1740. doi: 10.1016/0024-3205(81)90182-x. [DOI] [PubMed] [Google Scholar]
  20. Sonnenberg J. L., Sakane Y., Jeng A. Y., Koehn J. A., Ansell J. A., Wennogle L. P., Ghai R. D. Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney. Peptides. 1988 Jan-Feb;9(1):173–180. doi: 10.1016/0196-9781(88)90024-1. [DOI] [PubMed] [Google Scholar]
  21. Stewart J. J., Curd C. D. Antipropulsive effects of central and peripheral morphine in the rat gastrointestinal tract. J Pharm Pharmacol. 1984 Jul;36(7):476–477. doi: 10.1111/j.2042-7158.1984.tb04431.x. [DOI] [PubMed] [Google Scholar]
  22. Stewart J. J., Weisbrodt N. W., Burks T. F. Central and peripheral actions of morphine on intestinal transit. J Pharmacol Exp Ther. 1978 Jun;205(3):547–555. [PubMed] [Google Scholar]
  23. Stewart J. J., Weisbrodt N. W., Burks T. F. Centrally mediated intestinal stimulation by morphine. J Pharmacol Exp Ther. 1977 Jul;202(1):174–181. [PubMed] [Google Scholar]
  24. Weisbrodt N. W., Sussman S. S., Stewart J. J., Burks T. F. Effect of morphine sulfate on intestinal transit and myoelectric activity of the small intestine of the rat. J Pharmacol Exp Ther. 1980 Aug;214(2):333–338. [PubMed] [Google Scholar]

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