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. 1989 Oct;98(2):333–335. doi: 10.1111/j.1476-5381.1989.tb12599.x

Angiotensin converting enzyme activity is present in the endothelium-denuded aorta.

E Pipili 1, V G Manolopoulos 1, J D Catravas 1, M E Maragoudakis 1
PMCID: PMC1854739  PMID: 2555007

Abstract

Angiotensin converting enzyme activity was measured in intact aortic rings utilizing the synthetic tripeptide [3H]-benzoyl-Phe-Ala-Pro as the substrate. Intact aortic rings possessed angiotensin converting enzyme activity which was blocked by captopril. Enzyme activity was reduced by approximately 30% after removal of the endothelium by chemical or mechanical methods. The remaining activity was also captopril-sensitive. These results suggest that in addition to endothelium, angiotensin converting enzyme activity is present in other vascular cells and may contribute to the metabolism of angiotensin I generated within the vessel wall.

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Selected References

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