Abstract
Forty-four patients (43 female, 1 male), all with a history of recurrent urinary tract infections, were treated with 250 mg of amoxicillin plus 125 mg of clavulanic acid (one tablet of Augmentin) every 8 h for 7 days. The microbiological cure rates were 84% 1 week after the end of treatment and 67% 1 month later. Side effects, which were reported by 20% of the patients, were mild and in no case caused interruption of treatment. In view of the increasing trend in resistance to agents commonly used for the treatment of urinary tract infections in outpatients, the combination of amoxicillin and clavulanic acid may now be considered a first-line drug in patients with recurrent urinary tract infections.
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Selected References
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- Axelsson A., Jensen C., Melin O., Singer F., von Sydow C. Treatment of acute maxillary sinusitis. V. Amoxicillin azidocillin, phenylpropanolamine and pivampicillin. Acta Otolaryngol. 1981 Mar-Apr;91(3-4):313–318. doi: 10.3109/00016488109138513. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Hamilton-Miller J. M. Differential sensitivities to amoxycillin/clavulanate and amoxycillin in general practice urinary infections. Lancet. 1983 Sep 3;2(8349):566–566. doi: 10.1016/s0140-6736(83)90589-5. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Hamilton-Miller J. M., Dixson S., Gargan R. A., Gooding A. Phenomenon of resistance to Augmentin associated with sensitivity to ampicillin: occurrence and explanation. J Clin Pathol. 1983 Jun;36(6):670–673. doi: 10.1136/jcp.36.6.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brumfitt W., Hamilton-Miller J. M., Franklin I. N., Anderson F. M., Brown G. M. Conventional and two-dose amoxycillin treatment of bacteriuria in pregnancy and recurrent bacteriuria: a comparative study. J Antimicrob Chemother. 1982 Sep;10(3):239–248. doi: 10.1093/jac/10.3.239. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Hamilton-Miller J. M., Ludlam H., Damjanovic V., Gargan R. Comparative trial of trimethoprim and co-trimoxazole in recurrent urinary infections. Infection. 1982 Sep-Oct;10(5):280–284. doi: 10.1007/BF01640874. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Hamilton-Miller J. M., Wood A. Evidence for a slowing in trimethoprim resistance during 1981--a comparison with earlier years. J Antimicrob Chemother. 1983 Jun;11(6):503–509. doi: 10.1093/jac/11.6.503. [DOI] [PubMed] [Google Scholar]
- Copper J., Brumfitt W., Hamilton-Miller J. M. A comparative trial of co-trimoxazole and cephradine in patients with recurrent urinary infections. J Antimicrob Chemother. 1980 Mar;6(2):231–239. doi: 10.1093/jac/6.2.231. [DOI] [PubMed] [Google Scholar]
- Gargan R. A., Brumfitt W., Hamilton-Miller J. M. Antibody-coated bacteria in urine: criterion for a positive test and its value in defining a higher risk of treatment failure. Lancet. 1983 Sep 24;2(8352):704–706. doi: 10.1016/s0140-6736(83)92247-x. [DOI] [PubMed] [Google Scholar]
- Gargan R., Brumfitt W., Hamilton-Miller J. M. A concise biotyping system for differentiating strains of Escherichia coli. J Clin Pathol. 1982 Dec;35(12):1366–1369. doi: 10.1136/jcp.35.12.1366. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Iravani A., Richard G. A. Treatment of urinary tract infections with a combination of amoxicillin and clavulanic acid. Antimicrob Agents Chemother. 1982 Oct;22(4):672–677. doi: 10.1128/aac.22.4.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pagani L., Perduca M., Romero E. Prevalence and distribution of R plasmid mediated beta-lactamases in Enterobacteriaceae. Microbiologica. 1982 Jul;5(3):179–184. [PubMed] [Google Scholar]
- Price J. D., Harding J. W. The use of amoxycillin in treatment of urinary tract infection in general practice. Br J Clin Pract. 1973 May;27(5):165–169. [PubMed] [Google Scholar]
- Reading C., Cole M. Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May;11(5):852–857. doi: 10.1128/aac.11.5.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simpson I. N., Harper P. B., O'Callaghan C. H. Principal beta-lactamases responsible for resistance to beta-lactam antibiotics in urinary tract infections. Antimicrob Agents Chemother. 1980 Jun;17(6):929–936. doi: 10.1128/aac.17.6.929. [DOI] [PMC free article] [PubMed] [Google Scholar]