Abstract
A cis-diammineplatinum(II)-polyglutamic acid complex proved to have marked trypanocidal activity in vivo. When 5 mg of platinum per kg was administered daily for 5 days or when 20 mg of platinum per kg was administered on days 1, 3, and 6, five of five treated Trypanosoma congolense-infected mice were cured. In contrast, cis-platin was ineffective at all doses tested. We believe that the complex has a much higher therapeutic ratio than does uncomplexed drug because it is less toxic.
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Selected References
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- Connors T. A., Jones M., Ross W. C., Braddock P. D., Khokhar A. R., Tobe M. L. New platinum complexes with anti-tumour activity. Chem Biol Interact. 1972 Nov;5(6):415–424. doi: 10.1016/0009-2797(72)90078-6. [DOI] [PubMed] [Google Scholar]
- Kinnamon K. E., Steck E. A., Rane D. S. Activity of antitumor drugs against African trypanosomes. Antimicrob Agents Chemother. 1979 Feb;15(2):157–160. doi: 10.1128/aac.15.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lanham S. M., Godfrey D. G. Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose. Exp Parasitol. 1970 Dec;28(3):521–534. doi: 10.1016/0014-4894(70)90120-7. [DOI] [PubMed] [Google Scholar]
- Roberts J. J., Thomson A. J. The mechanism of action of antitumor platinum compounds. Prog Nucleic Acid Res Mol Biol. 1979;22:71–133. doi: 10.1016/s0079-6603(08)60799-0. [DOI] [PubMed] [Google Scholar]
- Williamson J., Scott-Finnigan T. J., Hardman M. A., Brown J. R. Trypanocidal activity of daunorubicin and related compounds. Nature. 1981 Jul 30;292(5822):466–467. doi: 10.1038/292466a0. [DOI] [PubMed] [Google Scholar]
- Wysor M. S., Zwelling L. A., Sanders J. E., Grenan M. M. Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue. Science. 1982 Jul 30;217(4558):454–456. doi: 10.1126/science.7201165. [DOI] [PubMed] [Google Scholar]