TABLE 1.
Suppressors rescue the lethal phenotype of mdf-1(gk2)
| Genotypes | Embryonic arrest (%) | Larval arrest (%) | Adult (%) | Fertile adult (%) | Male (%) |
|---|---|---|---|---|---|
| F2unc-46(e177) mdf-1(gk2) (n = 4133) | 25.2 | 53.4 | 21.4 | 2.5 | 5.1 |
| F2unc-46(e177) mdf-1(gk2) (n = 924) 25° | 97.3 | 2.7 | 0.0 | 0.0. | 0.0. |
| unc-46(e177) mdf-1(gk2); h1959ts (n = 829) | 14.6 | 16.4 | 69.0 | 57.1 | 1.5 |
| unc-46(e177) mdf-1(gk2); emb-30(tn377ts) (n = 1740) 16° | 11.4 | 16.5 | 72.1 | 50.4 | 0.7 |
| unc-46(e177) mdf-1(gk2); h1962ts (n = 455) | 19.4 | 14.5 | 66.1 | 48.1 | 3.1 |
| unc-46(e177) mdf-1(gk2); h1960 (n = 353) | 23.8 | 15.3 | 60.9 | 41.6 | 0.8 |
| unc-46(e177) mdf-1(gk2); h1958 (n = 585) | 24.9 | 22.2 | 52.9 | 40.6 | 1.8 |
| unc-46(e177) mdf-1(gk2); h1988ts (n = 470) | 28.8 | 28.9 | 42.3 | 33.9 | 2.5 |
| unc-46(e177) mdf-1(gk2) h1992 (n = 1135) | 45.3 | 15.0 | 39.7 | 30.7 | 1.8 |
| unc-46(e177) mdf-1(gk2); h1987 (n = 214) | 42.0 | 17.8 | 40.2 | 29.0 | 6.2 |
| unc-46(e177) mdf-1(gk2); fzy-1(h1983) (n = 1437) | 71.2 | 6.9 | 21.9 | 18.4 | 1.9 |
| unc-46(e177) mdf-1(gk2) h1985 (n = 1102) | 51.8 | 19.4 | 28.8 | 16.7 | 4.4 |
| unc-46(e177) mdf-1(gk2); h1989 (n = 989) | 70.1 | 9.3 | 20.6 | 12.6 | 3.9 |
| unc-46(e177) mdf-1(gk2) h2168 (n = 372) | 58.9 | 24.9 | 16.2 | 9.6 | 9.1 |
Shown are the phenotypes of the 11 mutants recovered in the screens for suppressors of the mdf-1(gk2) lethal phenotype. Also included are the two previously known suppressors emb-30(tn377ts) and fzy-1(h1983). The extent of suppression was determined at 20° after at least three backcrosses, unless otherwise indicated.