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. 1984 Mar;25(3):380–381. doi: 10.1128/aac.25.3.380

Production of hypoprothrombinemia by moxalactam and 1-methyl-5-thiotetrazole in rats.

J J Lipsky, J C Lewis, W J Novick Jr
PMCID: PMC185524  PMID: 6326667

Abstract

To determine whether the hypoprothrombinemia associated with antibiotics containing a 1-methyl-5-thiotetrazole (MTT) group is a result of the presence of the MTT group, rats were maintained on a vitamin K-deficient diet for 10 days and then received either intravenous moxalactam or cefotaxime or oral MTT for two additional days. MTT and moxalactam, which contains the MTT group, prolonged prothrombin time. Cefotaxime, which lacks the MTT group, had no effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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