Abstract
The four antiherpes compounds acyclovir, adenine arabinoside, bromovinyldeoxyuridine, and phosphonoformic acid showed an additive to synergistic effect with human leukocyte interferon in inhibiting focus formation by three different strains of varicella-zoster virus in human embryonic fibroblasts.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ayisi N. K., Gupta V. S., Meldrum J. B., Taneja A. K., Babiuk L. A. Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2. Antimicrob Agents Chemother. 1980 Apr;17(4):558–566. doi: 10.1128/aac.17.4.558. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Biron K. K., Elion G. B. Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro. Am J Med. 1982 Jul 20;73(1A):54–57. doi: 10.1016/0002-9343(82)90063-8. [DOI] [PubMed] [Google Scholar]
- Biron K. K., Elion G. B. In vitro susceptibility of varicella-zoster virus to acyclovir. Antimicrob Agents Chemother. 1980 Sep;18(3):443–447. doi: 10.1128/aac.18.3.443. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheng Y. C., Dutschman G., De Clercq E., Jones A. S., Rahim S. G., Verhelst G., Walker R. T. Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins. Mol Pharmacol. 1981 Jul;20(1):230–233. [PubMed] [Google Scholar]
- ELION G. B., SINGER S., HITCHINGS G. H. Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. J Biol Chem. 1954 Jun;208(2):477–488. [PubMed] [Google Scholar]
- Fischer P. H., Lee J. J., Chen M. S., Lin T. S., Prusoff W. H. Synergistic effect of 5'-amino-5'-deoxythymidine and 5-iodo-2'-deoxyuridine against Herpes Simplex virus infections in vitro. Biochem Pharmacol. 1979 Dec 1;28(23):3483–3486. doi: 10.1016/0006-2952(79)90092-3. [DOI] [PubMed] [Google Scholar]
- Levin M. J., Leary P. L. Inhibition of human herpesviruses by combination of acyclovir and human leukocyte interferon. Infect Immun. 1981 Jun;32(3):995–999. doi: 10.1128/iai.32.3.995-999.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shigeta S., Yokota T., Iwabuchi T., Baba M., Konno K., Ogata M., De Clercq E. Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus. J Infect Dis. 1983 Mar;147(3):576–584. doi: 10.1093/infdis/147.3.576. [DOI] [PubMed] [Google Scholar]
- Stanwick T. L., Schinazi R. F., Campbell D. E., Nahmias A. J. Combined antiviral effect of interferon and acyclovir on herpes simplex virus types 1 and 2. Antimicrob Agents Chemother. 1981 Apr;19(4):672–674. doi: 10.1128/aac.19.4.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wigand R., Hassinger M. Combined antiviral effect of DNA inhibitors on Herpes simplex virus multiplication. Med Microbiol Immunol. 1980;168(3):179–190. doi: 10.1007/BF02122852. [DOI] [PubMed] [Google Scholar]