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. 1984 Apr;25(4):522–523. doi: 10.1128/aac.25.4.522

Evaluation of lithium as an inhibitory agent of herpes simplex virus in cell cultures and during reactivation of latent infection in rabbits.

M D Trousdale, Y J Gordon, A C Peters, T I Gropen, E Nelson, A B Nesburn
PMCID: PMC185570  PMID: 6329084

Abstract

Lithium carbonate inhibited plaque formation of herpes simplex virus types 1 and 2 in rabbit kidney and Vero cells (50% effective dose, 435.5 to 490 micrograms/ml). Plasma lithium levels of 67 to 134 micrograms/ml were achieved by oral therapy in rabbits. However, neither ocular virus shedding nor virus-positive trigeminal ganglia were reduced after intentional reactivation of latent herpes simplex virus infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Casper R. C., Pandey G., Gosenfeld L., Davis J. M. Intracellular lithium and clinical response. Lancet. 1976 Aug 21;2(7982):418–419. doi: 10.1016/s0140-6736(76)92433-8. [DOI] [PubMed] [Google Scholar]
  2. Christensen S. Accumulation of lithium in the particulate fraction of rat brain following its long-term administration. J Neurochem. 1974 Dec;23(6):1299–1301. doi: 10.1111/j.1471-4159.1974.tb12231.x. [DOI] [PubMed] [Google Scholar]
  3. Hisayasu G. H., Cohen J. L., Nelson R. W. Determination of plasma and erythrocyte lithium concentrations by atomic absorption spectrophotometry. Clin Chem. 1977 Jan;23(1):41–45. [PubMed] [Google Scholar]
  4. Lieb J. Immunopotentiation and inhibition of herpes virus activation during therapy with lithium carbonate. Med Hypotheses. 1981 Jul;7(7):885–890. doi: 10.1016/0306-9877(81)90043-8. [DOI] [PubMed] [Google Scholar]
  5. Lieb J. Remission of recurrent herpes infection during therapy with lithium. N Engl J Med. 1979 Oct 25;301(17):942–942. doi: 10.1056/nejm197910253011711. [DOI] [PubMed] [Google Scholar]
  6. Mendels J., Frazer A. Intracellular lithium concentration and clinical response: towards a membrane theory of depression. J Psychiatr Res. 1973 Jun;10(1):9–18. doi: 10.1016/0022-3956(73)90005-8. [DOI] [PubMed] [Google Scholar]
  7. Pandey G. N., Davis J. M. Biology of the lithium ion. Adv Exp Med Biol. 1980;127:15–59. doi: 10.1007/978-1-4757-0259-0_2. [DOI] [PubMed] [Google Scholar]
  8. Shimomura Y., Gangarosa L. P., Sr, Kataoka M., Hill J. M. HSV-1 shedding by lontophoresis of 6-hydroxydopamine followed by topical epinephrine. Invest Ophthalmol Vis Sci. 1983 Dec;24(12):1588–1594. [PubMed] [Google Scholar]
  9. Skinner G. R., Hartley C., Buchan A., Harper L., Gallimore P. The effect of lithium chloride on the replication of herpes simplex virus. Med Microbiol Immunol. 1980;168(2):139–148. doi: 10.1007/BF02121762. [DOI] [PubMed] [Google Scholar]
  10. Trousdale M. D., Nesburn A. B., Su T. L., Lopez C., Watanabe K. A., Fox J. J. Activity of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)thymine against herpes simplex virus in cell cultures and rabbit eyes. Antimicrob Agents Chemother. 1983 Jun;23(6):808–813. doi: 10.1128/aac.23.6.808. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Trousdale M. D., Nesburn A. B., Watanabe K. A., Fox J. J. Evaluation of the antiherpetic activity of 2'-fluoro-5-iodo-ara-C in rabbit eyes and cell cultures. Invest Ophthalmol Vis Sci. 1981 Dec;21(6):826–832. [PubMed] [Google Scholar]

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