Figure 1 Histological changes in colonic biopsies and tumour necrosis factor α (TNF‐α) expression before and after infliximab therapy (haematoxylin‐eosin and immunohistochemical stains; original magnification 125× and 400×). (A) Active segmental colitis associated with diverticula (SCAD) characterised by a dense inflammatory infiltrate, disturbed crypt architecture, and epithelial damage, and by high TNF‐α expression (B). (C) SCAD in remission characterised by regression of the inflammatory infiltrate, restoration of the epithelial damage, and profound downregulation of TNF‐α expression (D).