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. 1982 Dec;22(6):942–948. doi: 10.1128/aac.22.6.942

Role of porin proteins OmpF and OmpC in the permeation of beta-lactams.

A Jaffe, Y A Chabbert, O Semonin
PMCID: PMC185697  PMID: 6760806

Abstract

Mutants of Escherichia coli K-12 lacking major outer membrane proteins were obtained by selecting for resistance to the beta-lactam cefoxitin. Three classes of resistant strains were found: mutants in ompB, a regulatory locus for proteins OmpF and OmpC; mutants in ompF; and one mutant in tpo. The OmpF and OmpC proteins facilitate penetration of beta-lactams through the outer membrane.

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Selected References

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