Abstract
The relationship of maximal oxygen uptake (VO2 max) with dihydrogenated ergot alkaloids was investigated in twelve young men. They were subjected to graded bicycle exercise with work loads corresponding to 75% and 120% of the load necessary to elicit VO2 max. The exercise tests were performed after intravenous administration of 2 mg dihydroergostin (DE-145) as well as after saline as control, both preparations were given double-blind. VO2 max averaged (SD) 3.36 (0.41) 1/min and no significant difference was disclosed between the DE-145 and the control situation. Normal relationships were observed between VO2 and work load, ventilation, heart rate, cardiac output, central venous pressure and acid-base data, and these relations were unaffected by DE-145 administration. Nausea was constantly seen in all subjects tested with DE-145. It is concluded, that the present dose of DE-145 has no influence on the functional capacity of the oxygen transporting system in sedentary young men.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ASMUSSEN E., NIELSEN M. Physiological dead space and alveolar gas pressures at rest and during muscular exercise. Acta Physiol Scand. 1956 Dec 29;38(1):1–21. doi: 10.1111/j.1748-1716.1957.tb00169.x. [DOI] [PubMed] [Google Scholar]
- Ingemann-Hansen T., Halkjaer-Kristensen J. Cigarette smoking and maximal oxygen consumption rate in humans. Scand J Clin Lab Invest. 1977 Apr;37(2):143–148. doi: 10.1080/00365517709156069. [DOI] [PubMed] [Google Scholar]
- Klausen K. Comparison of CO2 rebreathing and acetylene methods for cardiac output. J Appl Physiol. 1965 Jul;20(4):763–766. doi: 10.1152/jappl.1965.20.4.763. [DOI] [PubMed] [Google Scholar]
- Klausen K., Rasmussen B., Gjellerod H., Madsen H., Petersen E. Circulation, metabolism and ventilation during prolonged exposure to carbon monoxide and to high altitude. Scand J Clin Lab Invest Suppl. 1968;103:26–38. [PubMed] [Google Scholar]
- Mellander S., Nordenfelt I. Comparative effects of dihydroergotamine and noradrenaline on resistance, exchange and capacitance functions in the peripheral circulation. Clin Sci. 1970 Aug;39(2):183–201. doi: 10.1042/cs0390183. [DOI] [PubMed] [Google Scholar]
- Ulrich J., Siggaard-Andersen J. Vascular effects of dihydrogenated ergot alkaloids. Comparative effects of dihydroergostine and dihydroergotamine on the blood flow and the capacitance vessels in the human calf studied by plethysmography. Angiology. 1971 Dec;22(11):622–628. doi: 10.1177/000331977102201104. [DOI] [PubMed] [Google Scholar]