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. 1983 Nov;24(5):815–818. doi: 10.1128/aac.24.5.815

Effect of gentamicin treatment on adenylate cyclase and Na+, K+-ATPase activities in renal tissues of rats.

S F Queener, F C Luft, F G Hamel
PMCID: PMC185949  PMID: 6318658

Abstract

Gentamicin (20 mg/kg) treatment of male rats reduced Na+,K+-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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