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. 1983 Nov;24(5):823–826. doi: 10.1128/aac.24.5.823

Subinhibitory concentrations of antibiotics alter fibronectin binding to Staphylococcus aureus.

R A Proctor, P J Olbrantz, D F Mosher
PMCID: PMC185954  PMID: 6660855

Abstract

Fibronectin, a high-molecular-weight glycoprotein, is found in plasma and on mammalian cell surfaces. Recent reports have suggested that bacterial-fibronectin interactions play a role in bacterial attachment to host cells. Subinhibitory concentrations of lincosamines, erythromycin, and chloramphenicol decreased fibronectin binding to Staphylococcus aureus, whereas beta-lactam antibiotics enhanced this interaction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Lorian V., Atkinson B., Ewing W. H. Agglutination with O antisera of salmonella exposed to antibiotics. Am J Clin Pathol. 1976 Dec;66(6):1004–1011. doi: 10.1093/ajcp/66.6.1004. [DOI] [PubMed] [Google Scholar]
  2. Mosher D. F., Proctor R. A. Binding and factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus. Science. 1980 Aug 22;209(4459):927–929. doi: 10.1126/science.7403857. [DOI] [PubMed] [Google Scholar]
  3. Mosher D. F., Schad P. E. Cross-linking of fibronectin to collagen by blood coagulation Factor XIIIa. J Clin Invest. 1979 Sep;64(3):781–787. doi: 10.1172/JCI109524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Proctor R. A., Prendergast E., Mosher D. F. Fibronectin mediates attachment of Staphylococcus aureus to human neutrophils. Blood. 1982 Apr;59(4):681–687. [PubMed] [Google Scholar]
  5. Simpson W. A., Beachey E. H. Adherence of group A streptococci to fibronectin on oral epithelial cells. Infect Immun. 1983 Jan;39(1):275–279. doi: 10.1128/iai.39.1.275-279.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Woods D. E., Straus D. C., Johanson W. G., Jr, Bass J. A. Role of fibronectin in the prevention of adherence of Pseudomonas aeruginosa to buccal cells. J Infect Dis. 1981 Jun;143(6):784–790. doi: 10.1093/infdis/143.6.784. [DOI] [PubMed] [Google Scholar]

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