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. 1983 Feb;23(2):341–343. doi: 10.1128/aac.23.2.341

Ceftriaxone pharmacokinetics in newborn infants.

G H McCracken Jr, J D Siegel, N Threlkeld, M Thomas
PMCID: PMC186052  PMID: 6301369

Abstract

Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 micrograms/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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