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. 1996 May;148(5):1367–1373.

Chemokines and T lymphocyte recruitment to lymph nodes in HIV infection.

N Tedla 1, P Palladinetti 1, M Kelly 1, R K Kumar 1, N DiGirolamo 1, U Chattophadhay 1, B Cooke 1, P Truskett 1, J Dwyer 1, D Wakefield 1, A Lloyd 1
PMCID: PMC1861577  PMID: 8623908

Abstract

Recruitment of T lymphocytes to lymph nodes in patients with HIV infection is critical to the pathogenesis of disease. Chemokines are a family of cytokines, which are potent regulators of leukocyte migration. We studied the leukocyte populations and expression of chemokines known to be active upon T cells in lymph nodes of four HIV infected patients and seven control subjects using in situ hybridization, immunohistochemistry, and FACS analysis. The HIV lymph nodes showed CD8+ T lymphocyte accumulation and strongly enhanced chemokine expression, notably for the CD8+ T cell chemoattractant, macrophage inflammatory protein (MIP)-1 alpha. Resident macrophages appeared to be a major cellular source of chemokines in the HIV nodes. RANTES expression was present in both HIV and control lymph nodes, suggesting a physiological role for this chemokine in T lymphocyte recirculation. Chemokines may be important determinants of T lymphocyte accumulation in lymphoid tissue of patients with HIV/AIDS.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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