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. 1994 Feb;62(2):709–712. doi: 10.1128/iai.62.2.709-712.1994

Heterogeneous surface distribution of the fibrinogen-binding protein on Candida albicans.

J P Martínez 1, J L López-Ribot 1, W L Chaffin 1
PMCID: PMC186163  PMID: 8300229

Abstract

As detected by indirect immunofluorescence and confocal microscopy, fibrinogen binding was heterogeneously distributed on the surface of Candida albicans. A low level of binding was generally observed homogeneously distributed on some yeast and most hyphal extensions of germ tubes. However, on most hyphal extensions, there were randomly distributed areas of increased expression, as revealed by patches of greater fluorescence intensity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. M., Soll D. R. Unique phenotype of opaque cells in the white-opaque transition of Candida albicans. J Bacteriol. 1987 Dec;169(12):5579–5588. doi: 10.1128/jb.169.12.5579-5588.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson J., Cundiff L., Schnars B., Gao M. X., Mackenzie I., Soll D. R. Hypha formation in the white-opaque transition of Candida albicans. Infect Immun. 1989 Feb;57(2):458–467. doi: 10.1128/iai.57.2.458-467.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bouali A., Robert R., Tronchin G., Senet J. M. Binding of human fibrinogen to Candida albicans in vitro: a preliminary study. J Med Vet Mycol. 1986 Aug;24(4):345–348. doi: 10.1080/02681218680000511. [DOI] [PubMed] [Google Scholar]
  4. Bouali A., Robert R., Tronchin G., Senet J. M. Characterization of binding of human fibrinogen to the surface of germ-tubes and mycelium of candida albicans. J Gen Microbiol. 1987 Mar;133(3):545–551. doi: 10.1099/00221287-133-3-545. [DOI] [PubMed] [Google Scholar]
  5. Bouchara J. P., Tronchin G., Annaix V., Robert R., Senet J. M. Laminin receptors on Candida albicans germ tubes. Infect Immun. 1990 Jan;58(1):48–54. doi: 10.1128/iai.58.1.48-54.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Calderone R. A., Braun P. C. Adherence and receptor relationships of Candida albicans. Microbiol Rev. 1991 Mar;55(1):1–20. doi: 10.1128/mr.55.1.1-20.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Casanova M., Gil M. L., Cardeñoso L., Martinez J. P., Sentandreu R. Identification of wall-specific antigens synthesized during germ tube formation by Candida albicans. Infect Immun. 1989 Jan;57(1):262–271. doi: 10.1128/iai.57.1.262-271.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Casanova M., Lopez-Ribot J. L., Monteagudo C., Llombart-Bosch A., Sentandreu R., Martinez J. P. Identification of a 58-kilodalton cell surface fibrinogen-binding mannoprotein from Candida albicans. Infect Immun. 1992 Oct;60(10):4221–4229. doi: 10.1128/iai.60.10.4221-4229.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Casanova M., Martínez J. P., Chaffin W. L. Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans. Infect Immun. 1990 Nov;58(11):3810–3812. doi: 10.1128/iai.58.11.3810-3812.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cassone A. Cell wall of Candida albicans: its functions and its impact on the host. Curr Top Med Mycol. 1989;3:248–314. doi: 10.1007/978-1-4612-3624-5_10. [DOI] [PubMed] [Google Scholar]
  11. Chaffin W. L., Ringler L., Larsen H. S. Interactions of monospecific antisera with cell surface determinants of Candida albicans. Infect Immun. 1988 Dec;56(12):3294–3296. doi: 10.1128/iai.56.12.3294-3296.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Chaffin W. L., Skudlarek J., Morrow K. J. Variable expression of a surface determinant during proliferation of Candida albicans. Infect Immun. 1988 Feb;56(2):302–309. doi: 10.1128/iai.56.2.302-309.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kanbe T., Li R. K., Wadsworth E., Calderone R. A., Cutler J. E. Evidence for expression of the C3d receptor of Candida albicans in vitro and in vivo obtained by immunofluorescence and immunoelectron microscopy. Infect Immun. 1991 May;59(5):1832–1838. doi: 10.1128/iai.59.5.1832-1838.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Koch Y., Rademacher K. H. Chemical and enzymatic changes in the cell walls of Candida albicans and Saccharomyces cerevisiae by scanning electron microscopy. Can J Microbiol. 1980 Aug;26(8):965–970. doi: 10.1139/m80-164. [DOI] [PubMed] [Google Scholar]
  15. Lee K. L., Buckley H. R., Campbell C. C. An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida Albicans. Sabouraudia. 1975 Jul;13(2):148–153. doi: 10.1080/00362177585190271. [DOI] [PubMed] [Google Scholar]
  16. Lopez-Ribot J. L., Casanova M., Martinez J. P., Sentandreu R. Characterization of cell wall proteins of yeast and hydrophobic mycelial cells of Candida albicans. Infect Immun. 1991 Jul;59(7):2324–2332. doi: 10.1128/iai.59.7.2324-2332.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Mayer C. L., Diamond R. D., Edwards J. E., Jr Recognition of binding sites on Candida albicans by monoclonal antibodies to human leukocyte antigens. Infect Immun. 1990 Nov;58(11):3765–3769. doi: 10.1128/iai.58.11.3765-3769.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Page S., Odds F. C. Binding of plasma proteins to Candida species in vitro. J Gen Microbiol. 1988 Oct;134(10):2693–2702. doi: 10.1099/00221287-134-10-2693. [DOI] [PubMed] [Google Scholar]
  19. Tronchin G., Robert R., Bouali A., Senet J. M. Immunocytochemical localization of in vitro binding of human fibrinogen to Candida albicans germ tube and mycelium. Ann Inst Pasteur Microbiol. 1987 Mar-Apr;138(2):177–187. doi: 10.1016/0769-2609(87)90194-3. [DOI] [PubMed] [Google Scholar]

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